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AR096274A1 - Receptor quimérico de antígeno específico para cd19 y sus usos - Google Patents

Receptor quimérico de antígeno específico para cd19 y sus usos

Info

Publication number
AR096274A1
AR096274A1 ARP140101924A ARP140101924A AR096274A1 AR 096274 A1 AR096274 A1 AR 096274A1 AR P140101924 A ARP140101924 A AR P140101924A AR P140101924 A ARP140101924 A AR P140101924A AR 096274 A1 AR096274 A1 AR 096274A1
Authority
AR
Argentina
Prior art keywords
car
cell
ligand binding
chimeric antigen
chemeric
Prior art date
Application number
ARP140101924A
Other languages
English (en)
Inventor
Mannioui Ccile
Galetto Roman
Smith Julianne
Scharenberg Andrew
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48579464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR096274(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellectis filed Critical Cellectis
Publication of AR096274A1 publication Critical patent/AR096274A1/es

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Abstract

Receptores de antígenos quiméricos (CAR). Los CAR tienen la capacidad de redirigir la especificidad y reactividad de la célula inmune hacia un blanco seleccionado haciendo uso de las propiedades de dominio de unión a ligando. En particular, la presente se relaciona con un receptor quimérico de antígeno en donde la unión a ligando extracelular es un scFv derivado de un anticuerpo monoclonal contra CD19, preferentemente 4G7. La presente también se relaciona con polinucleótidos, vectores que codifican para dichos CAR y células aisladas que expresan dicho CAR en su superficie. La presente también se relaciona con métodos para diseñar células inmunes que expresan 4G7-CAR en su superficie que confiere un estado activado prolongado en la célula transducida. La presente es particularmente útil para el tratamiento de linfomas de células B y leucemia.
ARP140101924A 2012-05-25 2014-05-13 Receptor quimérico de antígeno específico para cd19 y sus usos AR096274A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261651933P 2012-05-25 2012-05-25
US201261696612P 2012-09-04 2012-09-04
PCT/US2013/040755 WO2013176915A1 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy

Publications (1)

Publication Number Publication Date
AR096274A1 true AR096274A1 (es) 2015-12-16

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ARP140101924A AR096274A1 (es) 2012-05-25 2014-05-13 Receptor quimérico de antígeno específico para cd19 y sus usos

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US (15) US10426795B2 (es)
EP (7) EP3473707B1 (es)
JP (5) JP6463672B2 (es)
KR (2) KR102247979B1 (es)
CN (3) CN111676196A (es)
AR (1) AR096274A1 (es)
AU (5) AU2013266734B2 (es)
BR (1) BR112014029417B1 (es)
CA (3) CA2874609C (es)
DK (2) DK3473707T3 (es)
EA (1) EA201492222A1 (es)
ES (2) ES3015120T3 (es)
HK (1) HK1245321A1 (es)
HU (2) HUE064187T2 (es)
IN (1) IN2014DN10991A (es)
MA (1) MA37681B2 (es)
MX (1) MX370265B (es)
MY (1) MY180127A (es)
NZ (1) NZ703281A (es)
PL (2) PL2855667T3 (es)
PT (2) PT3473707T (es)
SG (2) SG10201806573TA (es)
UA (1) UA118652C2 (es)
WO (2) WO2013176916A1 (es)
ZA (1) ZA201409536B (es)

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