AR074737A1 - Derivados de (4-terc-butilpiperazin-2-il) (piperazin-1-il) metanona-n-carboxamida y composicion farmaceutica que los contiene - Google Patents
Derivados de (4-terc-butilpiperazin-2-il) (piperazin-1-il) metanona-n-carboxamida y composicion farmaceutica que los contieneInfo
- Publication number
- AR074737A1 AR074737A1 ARP090104853A ARP090104853A AR074737A1 AR 074737 A1 AR074737 A1 AR 074737A1 AR P090104853 A ARP090104853 A AR P090104853A AR P090104853 A ARP090104853 A AR P090104853A AR 074737 A1 AR074737 A1 AR 074737A1
- Authority
- AR
- Argentina
- Prior art keywords
- carboxamide
- butilpiperazin
- metanona
- terc
- piperazin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- SRWQVWAIVQXPJY-QGZVFWFLSA-N 4-[(2r)-4-tert-butylpiperazine-2-carbonyl]-n-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide Chemical compound C1N(C(C)(C)C)CCN[C@H]1C(=O)N1CCN(C(=O)NC=2C=C(F)C(Cl)=CC=2)CC1 SRWQVWAIVQXPJY-QGZVFWFLSA-N 0.000 abstract 1
- 102000004497 CCR2 Receptors Human genes 0.000 abstract 1
- 108010017312 CCR2 Receptors Proteins 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a compuestos de fórmula (1). Los compuestos actúan a través del antagonismo del receptor CCR2b y pueden utilizarse para tratar una enfermedad inflamatoria y/o el dolor neuropático. Reivindicación 1: 4-[(2R)-4-terc-butilpiperazina-2-carbonil]-N-(4-cloro-3-fluorofenil) piperazina-1-carboxamida como una base o una sal farmacéuticamente aceptable de la misma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12244508P | 2008-12-15 | 2008-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074737A1 true AR074737A1 (es) | 2011-02-09 |
Family
ID=42241254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104853A AR074737A1 (es) | 2008-12-15 | 2009-12-14 | Derivados de (4-terc-butilpiperazin-2-il) (piperazin-1-il) metanona-n-carboxamida y composicion farmaceutica que los contiene |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20100152197A1 (es) |
| EP (2) | EP2379519A4 (es) |
| JP (1) | JP2012512153A (es) |
| KR (1) | KR20110099012A (es) |
| CN (1) | CN102317273A (es) |
| AR (1) | AR074737A1 (es) |
| AU (1) | AU2009327575B2 (es) |
| BR (1) | BRPI0922439A2 (es) |
| CA (1) | CA2746990A1 (es) |
| CL (1) | CL2011001436A1 (es) |
| CO (1) | CO6440554A2 (es) |
| CR (1) | CR20110332A (es) |
| CU (1) | CU20110133A7 (es) |
| DO (1) | DOP2011000191A (es) |
| EA (1) | EA201190019A1 (es) |
| EC (1) | ECSP11011131A (es) |
| IL (1) | IL213163A0 (es) |
| MX (1) | MX2011006087A (es) |
| NI (1) | NI201100125A (es) |
| PE (1) | PE20120082A1 (es) |
| TW (1) | TW201028400A (es) |
| UY (1) | UY32321A (es) |
| WO (1) | WO2010071567A1 (es) |
| ZA (1) | ZA201105219B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0519288A2 (pt) | 2004-12-24 | 2009-01-06 | Astrazeneca Ab | compostos heterocÍclicos como antagonistas de ccr2b |
| GB0525957D0 (en) * | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
| EP3570893A1 (en) | 2017-01-17 | 2019-11-27 | GlaxoSmithKline Intellectual Property Development Ltd | Non peptidic heterobivalent molecules for treating inflammatory diseases |
| US12319958B2 (en) | 2020-07-21 | 2025-06-03 | Rutgers, The State University Of New Jersey | Method and kit for CCR2 expression profiling and disease stratification |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133061A (en) * | 1962-11-13 | 1964-05-12 | Sterling Drug Inc | Piperidine carboxamides and derivatives thereof |
| US3541085A (en) * | 1969-05-09 | 1970-11-17 | American Cyanamid Co | Method of preparing thiotricyclic compounds |
| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
| WO2004110376A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
| BRPI0519288A2 (pt) | 2004-12-24 | 2009-01-06 | Astrazeneca Ab | compostos heterocÍclicos como antagonistas de ccr2b |
| GB0428327D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Ab | Method |
| GB0525957D0 (en) * | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
-
2009
- 2009-12-10 US US12/634,739 patent/US20100152197A1/en not_active Abandoned
- 2009-12-14 KR KR1020117013597A patent/KR20110099012A/ko not_active Withdrawn
- 2009-12-14 AU AU2009327575A patent/AU2009327575B2/en not_active Ceased
- 2009-12-14 BR BRPI0922439A patent/BRPI0922439A2/pt not_active IP Right Cessation
- 2009-12-14 AR ARP090104853A patent/AR074737A1/es not_active Application Discontinuation
- 2009-12-14 JP JP2011540662A patent/JP2012512153A/ja active Pending
- 2009-12-14 EA EA201190019A patent/EA201190019A1/ru unknown
- 2009-12-14 MX MX2011006087A patent/MX2011006087A/es active IP Right Grant
- 2009-12-14 TW TW098142762A patent/TW201028400A/zh unknown
- 2009-12-14 UY UY0001032321A patent/UY32321A/es not_active Application Discontinuation
- 2009-12-14 WO PCT/SE2009/051416 patent/WO2010071567A1/en not_active Ceased
- 2009-12-14 CA CA2746990A patent/CA2746990A1/en not_active Abandoned
- 2009-12-14 PE PE2011001229A patent/PE20120082A1/es not_active Application Discontinuation
- 2009-12-14 EP EP09833731A patent/EP2379519A4/en not_active Ceased
- 2009-12-14 EP EP14153398.4A patent/EP2727913A1/en not_active Withdrawn
- 2009-12-14 CN CN2009801567238A patent/CN102317273A/zh active Pending
-
2011
- 2011-05-26 CO CO11065428A patent/CO6440554A2/es not_active Application Discontinuation
- 2011-05-26 IL IL213163A patent/IL213163A0/en unknown
- 2011-06-13 CL CL2011001436A patent/CL2011001436A1/es unknown
- 2011-06-15 CU CU20110133A patent/CU20110133A7/es unknown
- 2011-06-15 NI NI201100125A patent/NI201100125A/es unknown
- 2011-06-15 DO DO2011000191A patent/DOP2011000191A/es unknown
- 2011-06-15 CR CR20110332A patent/CR20110332A/es not_active Application Discontinuation
- 2011-06-15 EC EC2011011131A patent/ECSP11011131A/es unknown
- 2011-07-14 ZA ZA2011/05219A patent/ZA201105219B/en unknown
-
2012
- 2012-07-25 US US13/557,559 patent/US20120289513A1/en not_active Abandoned
-
2013
- 2013-06-27 US US13/928,803 patent/US20130289043A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CU20110133A7 (es) | 2012-01-31 |
| AU2009327575B2 (en) | 2013-07-04 |
| CN102317273A (zh) | 2012-01-11 |
| EP2379519A4 (en) | 2012-06-20 |
| NI201100125A (es) | 2012-03-19 |
| AU2009327575A1 (en) | 2011-06-23 |
| EP2379519A1 (en) | 2011-10-26 |
| CO6440554A2 (es) | 2012-05-15 |
| IL213163A0 (en) | 2011-07-31 |
| DOP2011000191A (es) | 2011-07-15 |
| KR20110099012A (ko) | 2011-09-05 |
| TW201028400A (en) | 2010-08-01 |
| BRPI0922439A2 (pt) | 2017-06-06 |
| EA201190019A1 (ru) | 2012-02-28 |
| MX2011006087A (es) | 2011-06-21 |
| UY32321A (es) | 2010-07-30 |
| CL2011001436A1 (es) | 2011-08-26 |
| PE20120082A1 (es) | 2012-03-04 |
| CA2746990A1 (en) | 2010-06-24 |
| EP2727913A1 (en) | 2014-05-07 |
| WO2010071567A1 (en) | 2010-06-24 |
| ZA201105219B (en) | 2012-03-28 |
| CR20110332A (es) | 2011-08-05 |
| US20100152197A1 (en) | 2010-06-17 |
| ECSP11011131A (es) | 2011-07-29 |
| US20130289043A1 (en) | 2013-10-31 |
| US20120289513A1 (en) | 2012-11-15 |
| JP2012512153A (ja) | 2012-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |