AR074399A1 - Moleculas biespecificas de union a egfr/igfir - Google Patents
Moleculas biespecificas de union a egfr/igfirInfo
- Publication number
- AR074399A1 AR074399A1 ARP090104530A ARP090104530A AR074399A1 AR 074399 A1 AR074399 A1 AR 074399A1 AR P090104530 A ARP090104530 A AR P090104530A AR P090104530 A ARP090104530 A AR P090104530A AR 074399 A1 AR074399 A1 AR 074399A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- loop
- acid sequence
- amino acid
- amino acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Moléculas biespecíficas que comprenden un dominio de unión a EGFR y un dominio a IGFIR distinto para el uso en aplicaciones de diagnóstico, investigación y terapéuticas. Células que comprenden tales proteínas, a polinucleótidos que codifican tales proteínas o fragmentos de las mismas y a vectores que comprenden los polinucleótidos que codifican las proteínas innovadoras. Ejemplos de moléculas biespecíficas incluyen dímeros de proteína similar a anticuerpo basados en el décimo dominio de fibronectina de tipo III. Reivindicación 1: Un dímero de proteína similar a anticuerpo, caracterizado porque comprende a) un décimo dominio de fibronectina de tipo III (10Fn3) que se une a IGF-IR con una KD menor de 500 nM unido covalentemente o no covalentemente con b) un 10Fn3 que se une a EGFR con una KD menor de 500 nM; en el que el 10Fn3 de unión de IGF-IR comprende un bucle BC que tiene la secuencia de aminoácidos expuesta en los aminoácidos 21-30 de la SEC ID Ns 3, un bucle DE que tiene la secuencia de aminoácidos expuesta en los aminoácidos 51-56 de la SEC ID Ns 3 y un bucle FG que tiene la secuencia de aminoácidos expuesta en los aminoácidos 76-83 de la SEC ID Ns 3 y en el que el 10Fn3 de unión de EGFR comprende un bucle BC que tiene la secuencia de aminoácidos expuesta en los aminoácidos 21-30 de la SEC ID Ns 112, un bucle DE que tiene la secuencia de aminoácidos expuesta en los aminoácidos 51-56 de la SEC ID Ns 112 y un bucle FG que tiene la secuencia de aminoácidos expuesta en los aminoácidos 76-92 de la SEC ID Ns 112.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20016408P | 2008-11-24 | 2008-11-24 | |
| US20028208P | 2008-11-26 | 2008-11-26 | |
| US21296609P | 2009-04-17 | 2009-04-17 | |
| US17827909P | 2009-05-14 | 2009-05-14 | |
| US22733009P | 2009-07-21 | 2009-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074399A1 true AR074399A1 (es) | 2011-01-12 |
Family
ID=41667546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104530A AR074399A1 (es) | 2008-11-24 | 2009-11-24 | Moleculas biespecificas de union a egfr/igfir |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US8343501B2 (es) |
| EP (2) | EP2350126B1 (es) |
| JP (2) | JP5823870B2 (es) |
| KR (1) | KR20110098922A (es) |
| CN (1) | CN102439036B (es) |
| AR (1) | AR074399A1 (es) |
| AU (1) | AU2009316271A1 (es) |
| BR (1) | BRPI0922613A2 (es) |
| CA (1) | CA2744405A1 (es) |
| CL (1) | CL2011001214A1 (es) |
| CO (1) | CO6382161A2 (es) |
| EA (1) | EA022415B1 (es) |
| ES (1) | ES2555381T3 (es) |
| IL (1) | IL212715A0 (es) |
| MX (1) | MX2011005257A (es) |
| NZ (2) | NZ592782A (es) |
| PE (1) | PE20110587A1 (es) |
| TN (1) | TN2011000225A1 (es) |
| TW (1) | TWI496582B (es) |
| WO (1) | WO2010060095A1 (es) |
| ZA (1) | ZA201103766B (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06006406A (es) | 2003-12-05 | 2007-03-21 | Adnexus Therapeutics Inc | Inhibidores de receptores de factor de crecimiento endotelial vascular tipo 2. |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| BRPI0818810A2 (pt) | 2007-10-31 | 2014-10-29 | Medimmune Llc | Esqueletos d polipeptídeo recombinante e multimérico, molécula de ácido n ucleico isolado, vetor de expressão, célula hospedeira, biblioteca de exibição de polipeptídeo, coleção de moléculas de ácido nucleico isolado, métodos para obter um esqueleto de polipeptídeo e pelo menos dois esqueletos, para detectar um composto em uma amostra, para capturar um composto em uma amostra, para prevenir, tratar, controlar ou melhorar uma doença, para diagnose ou formação de imagem de uma doença para purificar e produzir um esqueleto, para ensaiar ou detectar a ligação de um esqueleto a um alvo, para usar o esqueleto e para prevenir, tratar, melhora ou controlar câncer, composição estéril, isenta de pirógeno, composição farmacêutica, e, processo escalável. |
| WO2009102421A2 (en) * | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| JP6192891B2 (ja) | 2008-05-02 | 2017-09-06 | ノバルティス アーゲー | 改善されたフィブロネクチンベースの結合分子およびそれらの使用 |
| JP2011520961A (ja) | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
| EP3128048B1 (en) | 2008-10-31 | 2018-11-28 | Janssen Biotech, Inc. | Fibronectin type iii domain based scaffold compositions, methods and uses |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| US8067201B2 (en) | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
| EP3434769B1 (en) | 2009-10-30 | 2020-11-25 | Novartis AG | Universal fibronectin type iii bottom-side binding domain libraries |
| WO2011103105A1 (en) | 2010-02-18 | 2011-08-25 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
| WO2011130324A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
| RU2767543C2 (ru) | 2010-04-30 | 2022-03-17 | Янссен Байотек, Инк. | Композиции на основе стабилизированных фибронектиновых доменов, способы и области их применения |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| US20130171185A1 (en) | 2010-07-06 | 2013-07-04 | Ethan Settembre | Norovirus derived immunogenic compositions and methods |
| CN107903321A (zh) * | 2010-07-30 | 2018-04-13 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
| US8580922B2 (en) | 2011-03-04 | 2013-11-12 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
| BR112013022557A2 (pt) * | 2011-03-04 | 2017-08-01 | Shire Human Genetic Therapies | ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos |
| ES2676499T3 (es) | 2011-04-13 | 2018-07-20 | Bristol-Myers Squibb Company | Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones |
| WO2012158739A1 (en) | 2011-05-17 | 2012-11-22 | Bristol-Myers Squibb Company | Improved methods for the selection of binding proteins |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN103827361A (zh) | 2011-09-27 | 2014-05-28 | 詹森生物科技公司 | 具有可供选择的结合表面的基于iii型纤连蛋白重复的蛋白质支架 |
| KR102132997B1 (ko) | 2011-10-11 | 2020-07-14 | 메디뮨 엘엘씨 | Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법 |
| EP2773659A2 (en) | 2011-10-31 | 2014-09-10 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| WO2013177187A2 (en) | 2012-05-22 | 2013-11-28 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and therapeutic agents |
| TW201843172A (zh) * | 2012-06-25 | 2018-12-16 | 美商再生元醫藥公司 | 抗－ｅｇｆｒ抗體及其用途 |
| AU2013315482B2 (en) | 2012-09-13 | 2018-03-15 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind to myostatin |
| US9695228B2 (en) * | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| US20150361159A1 (en) * | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| EP3406629B1 (en) | 2013-02-06 | 2020-06-24 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
| EP3617220B1 (en) | 2013-02-12 | 2021-03-24 | Bristol-Myers Squibb Company | High ph protein refolding methods |
| MX378238B (es) | 2013-10-14 | 2025-03-10 | Janssen Biotech Inc | Moléculas de unión con dominios de fibronectina de tipo iii modificadas con cisteína. |
| CN105916883B (zh) * | 2014-01-28 | 2019-12-03 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
| SG11201607820QA (en) | 2014-03-20 | 2016-10-28 | Bristol Myers Squibb Co | Serum albumin-binding fibronectin type iii domains |
| DK3180018T3 (da) | 2014-08-12 | 2019-10-28 | Massachusetts Inst Technology | Synergistisk tumorbehandling med IL-2 og integrinbindende Fc-fusionsprotein |
| WO2016025645A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
| AU2015353573B2 (en) | 2014-11-25 | 2020-09-03 | Bristol-Myers Squibb Company | Novel PD-L1 binding polypeptides for imaging |
| MX385081B (es) | 2014-11-25 | 2025-03-14 | Bristol Myers Squibb Co | Métodos y composiciones para radioetiquetado con 18f de productos biológicos. |
| EP4670785A2 (en) | 2015-01-02 | 2025-12-31 | Takeda Pharmaceutical Company Limited | Bispecific antibodies against plasma kallikrein and factor XII |
| AU2016297018B9 (en) | 2015-07-21 | 2022-12-01 | Takeda Pharmaceutical Company Limited | A monoclonal antibody inhibitor of factor XIIa |
| WO2017053617A1 (en) | 2015-09-23 | 2017-03-30 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type iii domains |
| US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
| EP3463486A1 (en) | 2016-06-01 | 2019-04-10 | Bristol-Myers Squibb Company | Pet imaging with pd-l1 binding polypeptides |
| MA45412A (fr) | 2016-06-21 | 2021-05-26 | Janssen Biotech Inc | Molécules de liaison au domaine de fibronectine de type iii modifiées par la cystéine |
| WO2018111978A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| RU2759952C2 (ru) | 2016-12-14 | 2021-11-19 | Янссен Байотек, Инк. | Cd8a-связывающие домены типа iii фибронектина |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| CA3049656A1 (en) | 2017-01-10 | 2018-07-19 | Nodus Therapeutics | Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator |
| US10350266B2 (en) | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
| EP3638300A4 (en) * | 2017-06-16 | 2021-06-23 | Protelica, Inc. | FIBRONECTIN-BINDING CHEMICAL ANTIGEN RECEPTORS AND METHODS OF USE |
| EP3684811A2 (en) | 2017-08-17 | 2020-07-29 | Massachusetts Institute of Technology | Multiple specificity binders of cxc chemokines and uses thereof |
| KR101943081B1 (ko) | 2017-08-31 | 2019-01-29 | (주)케어젠 | 주름 개선 활성을 나타내는 펩타이드 및 이의 용도 |
| US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| CN112771071A (zh) | 2018-09-28 | 2021-05-07 | 麻省理工学院 | 胶原蛋白定位的免疫调节分子及其方法 |
| US12410260B2 (en) * | 2019-01-11 | 2025-09-09 | The University Of North Carolina At Chapel Hill | Highly modular biepitopic and bispecific CAR-T cells for cancer immunotherapy |
| KR101959020B1 (ko) * | 2019-01-14 | 2019-03-18 | (주)케어젠 | 주름 개선 활성을 나타내는 펩타이드 및 이의 용도 |
| EP3914289A1 (en) | 2019-01-23 | 2021-12-01 | Massachusetts Institute of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| WO2021076546A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| EP4126923A2 (en) | 2020-03-31 | 2023-02-08 | Repertoire Immune Medicines, Inc. | Barcodable exchangeable peptide-mhc multimer libraries |
| WO2022087154A1 (en) | 2020-10-20 | 2022-04-28 | Repertoire Immune Medicines, Inc. | Mhc class ii peptide multimers and uses thereof |
| AU2022258584A1 (en) | 2021-04-14 | 2023-10-12 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| KR20240034160A (ko) | 2021-04-14 | 2024-03-13 | 에이알오 바이오테라퓨틱스 컴패니 | Cd71 결합 피브로넥틴 3형 도메인 |
| EP4504246A1 (en) | 2022-04-07 | 2025-02-12 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
Family Cites Families (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| US6018030A (en) | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5641648A (en) | 1986-11-04 | 1997-06-24 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| US5514581A (en) | 1986-11-04 | 1996-05-07 | Protein Polymer Technologies, Inc. | Functional recombinantly prepared synthetic protein polymer |
| US5770697A (en) | 1986-11-04 | 1998-06-23 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| JP2875884B2 (ja) | 1989-04-19 | 1999-03-31 | ノボ ノルディスク アクティーゼルスカブ | ポリペプチドの修飾に使用するための活性ポリアルキレンオキシドカーボネート |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| AU8498091A (en) | 1990-08-02 | 1992-03-02 | Regents Of The University Of Colorado, The | Systematic polypeptide evolution by reverse translation |
| JP3051145B2 (ja) | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| US5773574A (en) | 1990-12-03 | 1998-06-30 | The Scripps Research Institute | Polypeptides for promoting cell attachment |
| US5235041A (en) | 1990-12-28 | 1993-08-10 | Protein Polymer Technologies, Inc. | Purification of structurally ordered recombinant protein polymers |
| US5792742A (en) | 1991-06-14 | 1998-08-11 | New York University | Fibrin-binding peptide fragments of fibronectin |
| WO1993003172A1 (en) | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| EP0651761B1 (en) | 1992-07-13 | 2002-10-09 | Bionebraska, Inc. | Method for modification of recombinant polypeptides |
| PL174494B1 (pl) | 1992-11-13 | 1998-08-31 | Idec Pharma Corp | Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B |
| WO1994017097A1 (en) | 1993-01-19 | 1994-08-04 | Regents Of The University Of Minnesota | Synthetic fibronectin fragments as inhibitors of retroviral infections |
| PT654256E (pt) | 1993-02-26 | 2000-12-29 | Santen Pharmaceutical Co Ltd | Rolha de esclerotica biodegradavel |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5516522A (en) | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5559000A (en) | 1995-01-18 | 1996-09-24 | The Scripps Research Institute | Encoded reaction cassette |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6369116B1 (en) | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| DE19646372C1 (de) | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
| GB9618960D0 (en) | 1996-09-11 | 1996-10-23 | Medical Science Sys Inc | Proteases |
| US5922676A (en) | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
| EP0962527B1 (en) | 1996-10-17 | 2004-08-04 | Mitsubishi Chemical Corporation | Molecule that homologizes genotype and phenotype and utilization thereof |
| WO1998031794A1 (fr) | 1997-01-17 | 1998-07-23 | Toa Gosei Co., Ltd. | Polypeptide liant le facteur vegf |
| RU2233878C2 (ru) | 1997-01-21 | 2004-08-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| AU7266898A (en) | 1997-04-30 | 1998-11-24 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
| WO1998056915A2 (en) | 1997-06-12 | 1998-12-17 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| US6159722A (en) | 1997-12-03 | 2000-12-12 | Boehringer Mannheim Gmbh | Chimeric serine proteases |
| WO1999051773A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
| US20030045681A1 (en) | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| JP4108827B2 (ja) | 1998-05-28 | 2008-06-25 | 大日本印刷株式会社 | 無機質系化粧板 |
| CA2342967A1 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Modifying protein immunogenicity |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| JP4562286B2 (ja) | 1998-12-10 | 2010-10-13 | ブリストル−マイヤーズ スクウィブ カンパニー | 抗体模倣物および他の結合タンパク質のタンパク質骨格 |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| GB9827228D0 (en) | 1998-12-10 | 1999-02-03 | Univ Nottingham | Cancer detection method and reagents |
| US6887468B1 (en) | 1999-04-28 | 2005-05-03 | Board Of Regents, The University Of Texas System | Antibody kits for selectively inhibiting VEGF |
| ES2383332T3 (es) | 1999-07-27 | 2012-06-20 | Bristol-Myers Squibb Company | Procedimiento de ligación de aceptores de péptidos |
| US6399857B1 (en) | 1999-09-22 | 2002-06-04 | Paradigm Genetics, Inc. | Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species |
| WO2001072829A2 (en) | 2000-03-31 | 2001-10-04 | Institut Pasteur | Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof |
| JP2004515219A (ja) | 2000-06-15 | 2004-05-27 | ボード・オブ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | 調節可能な触媒活性な核酸 |
| EP2385067A1 (en) | 2000-07-11 | 2011-11-09 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| AU2001296962A1 (en) | 2000-09-29 | 2002-04-08 | Schering Corporation | Pegylated interleukin-10 |
| EP1356075A4 (en) | 2000-10-16 | 2005-04-13 | Compound Therapeutics Inc | PROTEIN EQUIPMENT FOR ANTIBODY MIMETICS AND OTHER TIE PROTEINS |
| US7598352B2 (en) | 2000-11-17 | 2009-10-06 | University Of Rochester | Method of identifying polypeptide monobodies which bind to target proteins and use thereof |
| AU3649502A (en) | 2000-11-29 | 2002-06-11 | Oculex Pharm Inc | Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
| US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
| AU2002307146B2 (en) | 2001-04-04 | 2007-02-01 | University Of Rochester | AlphaNuBeta3 integrin-binding polypeptide monobodies and their use |
| DK1390535T3 (da) | 2001-04-26 | 2010-12-06 | Amgen Mountain View Inc | Kombinatoriske biblioteker af monomer-domæner |
| US20030004561A1 (en) | 2001-06-28 | 2003-01-02 | Steve Bigus | Peeling sheath for self-expanding stent |
| AU2002342672A1 (en) | 2001-09-11 | 2003-03-24 | Nascacell Gmbh | Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes |
| US20080193445A1 (en) | 2002-01-18 | 2008-08-14 | Liliane Goetsch | Novel anti-IGF-IR antibodies and uses thereof |
| AR038535A1 (es) | 2002-02-22 | 2005-01-19 | Schering Corp | Formulaciones farmaceuticas de agentes antineoplasicos y procesos para prepararlos y usarlos |
| ATE510561T1 (de) | 2002-03-04 | 2011-06-15 | Imclone Llc | Kdr-spezifische menschliche antikörper und ihre verwendung |
| AU2003243436A1 (en) | 2002-06-06 | 2003-12-22 | Shohei Koide | Reconstituted polypeptides |
| ES2655912T3 (es) | 2002-11-08 | 2018-02-22 | Ablynx N.V. | Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos |
| US7053701B2 (en) | 2003-11-04 | 2006-05-30 | Vice Michael W | Power amplifier output stage with multiple power states and improved efficiency |
| CN102400990B (zh) | 2003-11-17 | 2014-08-20 | 远程接合技术公司 | 固定器组件 |
| US20080220049A1 (en) | 2003-12-05 | 2008-09-11 | Adnexus, A Bristol-Myers Squibb R&D Company | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins |
| MXPA06006406A (es) | 2003-12-05 | 2007-03-21 | Adnexus Therapeutics Inc | Inhibidores de receptores de factor de crecimiento endotelial vascular tipo 2. |
| US20070059336A1 (en) | 2004-04-30 | 2007-03-15 | Allergan, Inc. | Anti-angiogenic sustained release intraocular implants and related methods |
| WO2005110374A1 (en) | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US20060182783A1 (en) | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| EP1786918A4 (en) | 2004-07-17 | 2009-02-11 | Imclone Systems Inc | NEW BISPECIFIC ANTIBODY TETRAVALENT |
| US7597884B2 (en) * | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| BRPI0516308A2 (pt) | 2004-10-04 | 2010-06-15 | Qlt Usa Inc | composição fluida, métodos de tratamento de uma doença ou disfunção, métodos de liberação local ou sistêmica de um agente biológico, implantes, método de formação de um implante, kit de agente biológico e usos de uma composição fluida |
| JP2008521911A (ja) | 2004-12-02 | 2008-06-26 | シェーリング コーポレイション | 癌の処置において髄腔内にテモゾロミド処方物を使用する方法 |
| JP2008531557A (ja) | 2005-02-23 | 2008-08-14 | メリマック ファーマシューティカルズ インコーポレーティッド | 生物活性を調節するための二重特異性結合剤 |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US7887273B2 (en) | 2005-09-15 | 2011-02-15 | Newfrey Llc | Blind rivet and method |
| US20070072933A1 (en) | 2005-09-26 | 2007-03-29 | Peyman Gholam A | Delivery of an ocular agent |
| AP2008004418A0 (en) * | 2005-10-07 | 2008-04-30 | Univ California | Nucleic acids encoding modified cytochrome p450 enzyme and methods of use thereof |
| CA2602577C (en) | 2005-10-18 | 2015-03-31 | Allergan, Inc. | Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues |
| US20070099879A1 (en) | 2005-10-31 | 2007-05-03 | Wisconsin Alumni Research Foundation (Warf) | Method of using calcitriol for treating intraocular diseases associated with angiogenesis |
| BRPI0520677A2 (pt) | 2005-11-09 | 2009-05-19 | Bayer Schering Pharma Ag | identificação e caracterização de anticorpos de função de bloqueio anti-ed-b-fibronectina |
| PT1973559E (pt) * | 2005-11-23 | 2013-02-19 | Acceleron Pharma Inc | Antagonistas de activina-actriia e utilizações para promover o crescimento ósseo |
| CA2640080A1 (en) | 2006-02-02 | 2008-03-13 | Allergan, Inc. | Compositions and methods for the treatment of ophthalmic disease |
| AU2007218318A1 (en) * | 2006-02-24 | 2007-08-30 | Chiesi Farmaceutici S.P.A. | Anti-amyloid immunogenic compositions, methods and uses |
| WO2007121894A2 (en) * | 2006-04-21 | 2007-11-01 | Transgene S.A. | Hpv-18-based papillomavirus vaccine |
| US20070269422A1 (en) | 2006-05-17 | 2007-11-22 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| WO2008019290A2 (en) | 2006-08-04 | 2008-02-14 | Astrazeneca Ab | Human antibodies to erbb 2 |
| WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
| JP2010507099A (ja) * | 2006-10-16 | 2010-03-04 | ザ アリゾナ ボード オブ リージェンツ ア ボディ コーポレイト オブ ザ ステイト オブ アリゾナ アクティング フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティー | 合成抗体 |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| US8476243B2 (en) * | 2006-12-29 | 2013-07-02 | Transderm, Inc. | Methods and compositions for treating keratin hyperproliferative disorders |
| WO2008097497A2 (en) | 2007-02-02 | 2008-08-14 | Adnexus, A Bristol-Myers Squibb R & D Company | Vegf pathway blockade |
| EP2129397B1 (en) | 2007-03-02 | 2018-10-31 | Amgen, Inc. | Methods and compositions for treating tumor diseases |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US20090176654A1 (en) | 2007-08-10 | 2009-07-09 | Protelix, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| EP2197476A2 (en) | 2007-08-20 | 2010-06-23 | Bristol-Myers Squibb Company | Use of vegfr-2 inhibitors for treating metastatic cancer |
| CA2971794C (en) | 2007-10-04 | 2020-03-24 | Zymogenetics, Inc. | B7 family member zb7h6 and related compositions and methods |
| BRPI0818810A2 (pt) | 2007-10-31 | 2014-10-29 | Medimmune Llc | Esqueletos d polipeptídeo recombinante e multimérico, molécula de ácido n ucleico isolado, vetor de expressão, célula hospedeira, biblioteca de exibição de polipeptídeo, coleção de moléculas de ácido nucleico isolado, métodos para obter um esqueleto de polipeptídeo e pelo menos dois esqueletos, para detectar um composto em uma amostra, para capturar um composto em uma amostra, para prevenir, tratar, controlar ou melhorar uma doença, para diagnose ou formação de imagem de uma doença para purificar e produzir um esqueleto, para ensaiar ou detectar a ligação de um esqueleto a um alvo, para usar o esqueleto e para prevenir, tratar, melhora ou controlar câncer, composição estéril, isenta de pirógeno, composição farmacêutica, e, processo escalável. |
| WO2009073115A1 (en) | 2007-11-28 | 2009-06-11 | Bristol-Myers Squibb Company | Combination vegfr2 therapy with mtor inhibitors |
| AU2008345674A1 (en) | 2007-12-19 | 2009-07-09 | Centocor, Ortho Biotech Inc. | Alternative scaffold protein fusions phage display via fusion to pIX of M13 phage |
| BRPI0821924A2 (pt) | 2007-12-27 | 2015-07-07 | Novartis Ag | Moléculas de ligação baseadas em fibronectina melhoradas e seu uso |
| WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| JP6192891B2 (ja) | 2008-05-02 | 2017-09-06 | ノバルティス アーゲー | 改善されたフィブロネクチンベースの結合分子およびそれらの使用 |
| JP2011520961A (ja) | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
| US8415291B2 (en) | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
| EP3128048B1 (en) | 2008-10-31 | 2018-11-28 | Janssen Biotech, Inc. | Fibronectin type iii domain based scaffold compositions, methods and uses |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| KR20110104052A (ko) | 2008-12-16 | 2011-09-21 | 노파르티스 아게 | 효모 디스플레이 시스템 |
| EP2396000A1 (en) | 2009-02-11 | 2011-12-21 | Bristol-Myers Squibb Company | Combination vegfr2 therapy with temozolomide |
| RU2562700C2 (ru) | 2009-02-12 | 2015-09-10 | Янссен Байотек, Инк. | Композиции, способы получения и применение каркаса на основе домена фибронектина типа iii |
| US8067201B2 (en) * | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
| EP2464663A4 (en) | 2009-08-13 | 2013-05-29 | Massachusetts Inst Technology | MANIPULATED PROTEINS WITH MUTANT FIBRONECTIN DOMAINS |
| EP3434769B1 (en) | 2009-10-30 | 2020-11-25 | Novartis AG | Universal fibronectin type iii bottom-side binding domain libraries |
| WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
| US20110123545A1 (en) | 2009-11-24 | 2011-05-26 | Bristol-Myers Squibb Company | Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases |
| WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
| WO2011100700A2 (en) | 2010-02-12 | 2011-08-18 | University Of Rochester | Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies |
| WO2011103105A1 (en) | 2010-02-18 | 2011-08-25 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
| WO2011130324A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
| MX2012011781A (es) | 2010-04-13 | 2012-11-16 | Squibb Bristol Myers Co | Proteinas de dominio de armazon basadas en fibronectina que se unen a la proteina convertasa subtilisina kexina tipo q (pcsk9). |
| RU2767543C2 (ru) | 2010-04-30 | 2022-03-17 | Янссен Байотек, Инк. | Композиции на основе стабилизированных фибронектиновых доменов, способы и области их применения |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| CN107903321A (zh) | 2010-07-30 | 2018-04-13 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
| US9260496B2 (en) | 2010-12-22 | 2016-02-16 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind IL-23 |
| ES2676499T3 (es) | 2011-04-13 | 2018-07-20 | Bristol-Myers Squibb Company | Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones |
| WO2012158739A1 (en) | 2011-05-17 | 2012-11-22 | Bristol-Myers Squibb Company | Improved methods for the selection of binding proteins |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN103827361A (zh) | 2011-09-27 | 2014-05-28 | 詹森生物科技公司 | 具有可供选择的结合表面的基于iii型纤连蛋白重复的蛋白质支架 |
-
2009
- 2009-11-20 TW TW098139570A patent/TWI496582B/zh not_active IP Right Cessation
- 2009-11-24 ES ES09760433.4T patent/ES2555381T3/es active Active
- 2009-11-24 WO PCT/US2009/065765 patent/WO2010060095A1/en not_active Ceased
- 2009-11-24 NZ NZ592782A patent/NZ592782A/xx unknown
- 2009-11-24 EP EP09760433.4A patent/EP2350126B1/en not_active Not-in-force
- 2009-11-24 PE PE2011001073A patent/PE20110587A1/es not_active Application Discontinuation
- 2009-11-24 US US12/625,217 patent/US8343501B2/en active Active
- 2009-11-24 KR KR1020117014484A patent/KR20110098922A/ko not_active Ceased
- 2009-11-24 BR BRPI0922613A patent/BRPI0922613A2/pt not_active IP Right Cessation
- 2009-11-24 MX MX2011005257A patent/MX2011005257A/es active IP Right Grant
- 2009-11-24 EA EA201100669A patent/EA022415B1/ru not_active IP Right Cessation
- 2009-11-24 CA CA2744405A patent/CA2744405A1/en not_active Abandoned
- 2009-11-24 EP EP15192336.4A patent/EP3029064A1/en not_active Withdrawn
- 2009-11-24 AR ARP090104530A patent/AR074399A1/es unknown
- 2009-11-24 JP JP2011537719A patent/JP5823870B2/ja not_active Expired - Fee Related
- 2009-11-24 CN CN200980155318.4A patent/CN102439036B/zh not_active Expired - Fee Related
- 2009-11-24 AU AU2009316271A patent/AU2009316271A1/en not_active Abandoned
- 2009-11-24 NZ NZ601693A patent/NZ601693A/en unknown
-
2011
- 2011-05-05 IL IL212715A patent/IL212715A0/en unknown
- 2011-05-06 TN TN2011000225A patent/TN2011000225A1/fr unknown
- 2011-05-23 ZA ZA2011/03766A patent/ZA201103766B/en unknown
- 2011-05-24 CL CL2011001214A patent/CL2011001214A1/es unknown
- 2011-05-24 CO CO11064214A patent/CO6382161A2/es active IP Right Grant
-
2012
- 2012-12-03 US US13/692,555 patent/US9017655B2/en active Active
-
2015
- 2015-03-20 US US14/664,290 patent/US9771411B2/en active Active
- 2015-07-02 JP JP2015133521A patent/JP2016000731A/ja active Pending
-
2017
- 2017-08-23 US US15/684,595 patent/US10183987B2/en active Active
-
2018
- 2018-11-30 US US16/206,551 patent/US10954286B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR074399A1 (es) | Moleculas biespecificas de union a egfr/igfir | |
| ES2573108T3 (es) | Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada | |
| AR071874A1 (es) | Proteinas de dominio de armazon basadas en fibronectina multivalentes | |
| CY1122691T1 (el) | Πρωτεϊνες δεσμευσης αλβουμινης ορου | |
| AR077088A1 (es) | Proteinas biespecificas de union a antigeno | |
| UY31123A1 (es) | Proteinas de fusion natriureticas | |
| AR109355A2 (es) | Moléculas de unión al receptor ox40 humano | |
| AR080229A1 (es) | Proteinas de dominio de armazon de fibronectina que se unen a il -23 (interleucina 23) | |
| EA201490262A1 (ru) | Модифицированные белки и пептиды | |
| CY1123618T1 (el) | Πολυπεπτιδια αντισωματα που ανταγωνιζονται cd40l | |
| AR080793A1 (es) | Anticuerpos biespecificos | |
| EA201400568A1 (ru) | Альбуминсвязывающие антитела и их связывающие фрагменты | |
| AR076797A1 (es) | Anticuerpos triespecificos o tetraespecificos | |
| MX2015000397A (es) | Complejo del factor viii con xten y proteina del factor von willebrand, y sus usos. | |
| BR112018005573A2 (pt) | ?polipeptídeos de ligação a cd3? | |
| ECSP13013102A (es) | Dominios no inmunizados que se unen al suero y su uso para extender la vida media en el suero | |
| EA201001734A1 (ru) | Улучшенные связывающие молекулы на основе фибронектина и их применение | |
| CL2012001258A1 (es) | Un polipeptido de factor de von willebrand (fvw) aislado que comprende un dominio de union a factor viii (fviii), donde dicho polipeptido carece de algunos dominios del fvw, comprende una secuencia de aminoacidos de fc de inmunoglobulina; composicion y complejo proteico que lo comprende; celula que expresa dicho polipeptido; celula que expresa dicho complejo proteico; composición que comprende el complejo proteico. | |
| AR091069A1 (es) | Proteinas de union a antigeno dirigidas contra el receptor st2 | |
| CO6630173A2 (es) | Moléculas de unión a seroalbuminae | |
| RU2013110876A (ru) | Активируемые биспецифические антитела | |
| MX353382B (es) | Moleculas de union polipeptido de larga duracion. | |
| AR064707A1 (es) | Moleculas de transorte utilizando polipeptidos hiv -tat de secuencia inversa | |
| RU2015152077A (ru) | Тримерные антигенсвязывающие молекулы | |
| EA201400046A1 (ru) | Удаление клеток-мишеней с помощью циркулирующих вирусспецифических цитотоксических т-клеток с использованием содержащих гкгс класса i комплексов |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |