AR065477A1 - Diaminopirimidinas - Google Patents
DiaminopirimidinasInfo
- Publication number
- AR065477A1 AR065477A1 ARP080100785A ARP080100785A AR065477A1 AR 065477 A1 AR065477 A1 AR 065477A1 AR P080100785 A ARP080100785 A AR P080100785A AR P080100785 A ARP080100785 A AR P080100785A AR 065477 A1 AR065477 A1 AR 065477A1
- Authority
- AR
- Argentina
- Prior art keywords
- halo
- alkoxy
- diaminopirimidins
- disorder
- aminosulfonyl
- Prior art date
Links
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000026723 Urinary tract disease Diseases 0.000 abstract 1
- 208000012931 Urologic disease Diseases 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos de la formula (1) o una sal farmacéuticamente aceptable del mismo. R1 es alcoxi C1-6, hidroxi o halo; y R2 es alcoxi C1-6, halo, alquilo C1-6; alquilsulfonilo C1-6 o aminosulfonilo. Composicion farmacéutica, método para obtener (1) y parapreparar medicamento para enfermedad del tracto urinario, un estado patologico doloroso, un trastorno respiratorio o trastorno gastrointestinal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90407907P | 2007-02-28 | 2007-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065477A1 true AR065477A1 (es) | 2009-06-10 |
Family
ID=39297415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100785A AR065477A1 (es) | 2007-02-28 | 2008-02-26 | Diaminopirimidinas |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080207655A1 (es) |
| AR (1) | AR065477A1 (es) |
| CL (1) | CL2008000554A1 (es) |
| PE (1) | PE20090624A1 (es) |
| TW (1) | TW200845995A (es) |
| WO (1) | WO2008104474A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5128603B2 (ja) * | 2006-10-04 | 2013-01-23 | エフ．ホフマン−ラ ロシュ アーゲー | フェノキシジアミノピリミジン誘導体の合成方法 |
| US8785694B2 (en) | 2012-06-05 | 2014-07-22 | Connora Technologies, Inc | Processes for the preparation of di-(2-aminoethyl) formal, di-(3-aminopropyl) formal, and related molecules |
| NZ716977A (en) * | 2013-08-23 | 2017-09-29 | Afferent Pharmaceuticals Inc | Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of acute and sub-acute cough, urge to cough and chronic cough, in respiratory diseases |
| WO2017058645A1 (en) * | 2015-09-29 | 2017-04-06 | Afferent Pharmaceuticals, Inc. | Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough |
| US10822311B2 (en) | 2016-03-14 | 2020-11-03 | Afferent Pharmaceuticals, Inc. | Pyrimidines and variants thereof, and uses therefor |
| MX384368B (es) * | 2016-03-25 | 2025-03-14 | Afferent Pharmaceuticals Inc | Pirimidinas y sus variantes, y usos de las mismas. |
| CA3046027A1 (en) * | 2016-12-20 | 2018-06-28 | Prabha Ibrahim | Crystalline salts and polymorphs of a p2x3 antagonist |
| US11124473B2 (en) | 2017-07-11 | 2021-09-21 | Aditya Birla Chemicals (Usa) Llc | Salts of diaminoacetals and diaminoketals and their synthesis, and their transformations to diaminoacetals and diaminoketals |
| CN114007620B (zh) * | 2019-04-30 | 2024-08-06 | 北京泰德制药股份有限公司 | 二氨基嘧啶类化合物治疗子宫内膜异位相关的疼痛的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2557372C (en) * | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| ES2562056T3 (es) * | 2005-09-01 | 2016-03-02 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores P2X3 y P2X2/3 |
| PL1924264T3 (pl) * | 2005-09-01 | 2014-03-31 | Hoffmann La Roche | Diaminopirymidyny jako modulatory P2X<sub>3</sub> I P2X<sub>2/3</sub> |
| JP4850911B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン |
-
2008
- 2008-02-18 WO PCT/EP2008/051944 patent/WO2008104474A1/en not_active Ceased
- 2008-02-25 CL CL200800554A patent/CL2008000554A1/es unknown
- 2008-02-25 PE PE2008000379A patent/PE20090624A1/es not_active Application Discontinuation
- 2008-02-25 TW TW097106480A patent/TW200845995A/zh unknown
- 2008-02-26 AR ARP080100785A patent/AR065477A1/es unknown
- 2008-02-27 US US12/072,664 patent/US20080207655A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008000554A1 (es) | 2008-08-29 |
| PE20090624A1 (es) | 2009-05-16 |
| US20080207655A1 (en) | 2008-08-28 |
| WO2008104474A1 (en) | 2008-09-04 |
| TW200845995A (en) | 2008-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |