AR058078A1 - TEGASEROD MALEATE AND OBTAINING PROCESSES - Google Patents
TEGASEROD MALEATE AND OBTAINING PROCESSESInfo
- Publication number
- AR058078A1 AR058078A1 ARP060104386A ARP060104386A AR058078A1 AR 058078 A1 AR058078 A1 AR 058078A1 AR P060104386 A ARP060104386 A AR P060104386A AR P060104386 A ARP060104386 A AR P060104386A AR 058078 A1 AR058078 A1 AR 058078A1
- Authority
- AR
- Argentina
- Prior art keywords
- iodhydrate
- tegaserod
- pentylcarbazimidamide
- ylmethylene
- indole
- Prior art date
Links
- DJHHDLMTUOLVHY-UHFFFAOYSA-N 1,2,3,4-tetrachlorodibenzodioxine Chemical compound C1=CC=C2OC3=C(Cl)C(Cl)=C(Cl)C(Cl)=C3OC2=C1 DJHHDLMTUOLVHY-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960004354 tegaserod maleate Drugs 0.000 title abstract 2
- IKBKZGMPCYNSLU-UHFFFAOYSA-N 1-[(5-methoxy-1H-indol-3-yl)methylideneamino]-2-pentylguanidine Chemical compound C1=C(OC)C=C2C(C=NNC(=N)NCCCCC)=CNC2=C1 IKBKZGMPCYNSLU-UHFFFAOYSA-N 0.000 abstract 2
- IKBKZGMPCYNSLU-RGVLZGJSSA-N tegaserod Chemical compound C1=C(OC)C=C2C(/C=N/NC(=N)NCCCCC)=CNC2=C1 IKBKZGMPCYNSLU-RGVLZGJSSA-N 0.000 abstract 2
- 229960002876 tegaserod Drugs 0.000 abstract 2
- AORPQIVHOGZKAT-UHFFFAOYSA-N 1-[(5-methoxy-1H-indol-3-yl)methylideneamino]-2-pentylguanidine hydroiodide Chemical group I.COC=1C=C2C(=CNC2=CC1)C=NNC(NCCCCC)=N AORPQIVHOGZKAT-UHFFFAOYSA-N 0.000 abstract 1
- MZEJHDCUHDWXSE-UHFFFAOYSA-N 1-amino-2-pentylguanidine Chemical compound CCCCCNC(=N)NN MZEJHDCUHDWXSE-UHFFFAOYSA-N 0.000 abstract 1
- TUWARWGEOHQXCO-UHFFFAOYSA-N 5-methoxyindole-3-carbaldehyde Chemical compound COC1=CC=C2NC=C(C=O)C2=C1 TUWARWGEOHQXCO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente provee un proceso para preparar maleato ácido de 3-(5-metoxi-1H-indol-3- ilmetilen)-N-pentilcarbazimidamida (es decir, maleato de tegaserod). Este proceso incluye hacer reaccionar 5-metoxiindol-3-carbaldehído con iodhidrato de N-pentil- N'-aminoguanidina y aislar el iodhidrato de 3-(5-metoxi-1H-indol-3-ilmetilen)-N-pentilcarbazimidamida (es decir, iodhidrato de tegaserod) solido. Reivindicacion 1: Un compuesto, caracterizado porque es iodhidrato de 3-(5-metoxi-1H-indol-3- ilmetilen)-N-pentilcarbazimidamida (iodhidrato de tegaserod).This provides a process for preparing 3- (5-methoxy-1H-indole-3-ylmethylene) -N-pentylcarbazimidamide (ie, tegaserod maleate) maleate acid. This process includes reacting 5-methoxyindole-3-carbaldehyde with N-pentyl-N'-aminoguanidine iodhydrate and isolating 3- (5-methoxy-1H-indole-3-ylmethylene) -N-pentylcarbazimidamide iodhydrate (i.e. , tegaserod iodhydrate) solid. Claim 1: A compound, characterized in that it is 3- (5-methoxy-1H-indole-3-ylmethylene) -N-pentylcarbazimidamide iodide (tegaserod iodhydrate).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72396205P | 2005-10-06 | 2005-10-06 | |
| US72528205P | 2005-10-12 | 2005-10-12 | |
| US80896006P | 2006-05-30 | 2006-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058078A1 true AR058078A1 (en) | 2008-01-23 |
Family
ID=38514208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104386A AR058078A1 (en) | 2005-10-06 | 2006-10-05 | TEGASEROD MALEATE AND OBTAINING PROCESSES |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR058078A1 (en) |
| WO (1) | WO2007119109A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010015794A1 (en) * | 2008-08-07 | 2010-02-11 | Generics [Uk] Limited | Novel polymorphic forms of tegaserod |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY137386A (en) * | 2003-07-24 | 2009-01-30 | Novartis Ag | Stable modifications of tegaserod hydrogen maleate |
| WO2006116953A1 (en) * | 2005-05-02 | 2006-11-09 | Zentiva, A.S. | A method for the preparation of tegaserod and slected salts thereof |
-
2006
- 2006-10-05 WO PCT/IB2006/004222 patent/WO2007119109A2/en not_active Ceased
- 2006-10-05 AR ARP060104386A patent/AR058078A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007119109A3 (en) | 2008-06-12 |
| WO2007119109A2 (en) | 2007-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |