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AR039727A1 - Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas - Google Patents

Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas

Info

Publication number
AR039727A1
AR039727A1 ARP030102259A ARP030102259A AR039727A1 AR 039727 A1 AR039727 A1 AR 039727A1 AR P030102259 A ARP030102259 A AR P030102259A AR P030102259 A ARP030102259 A AR P030102259A AR 039727 A1 AR039727 A1 AR 039727A1
Authority
AR
Argentina
Prior art keywords
antibacterial agents
difluorotioacetamids
oxazolidinone
pharmaceutical composition
composition based
Prior art date
Application number
ARP030102259A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR039727A1 publication Critical patent/AR039727A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Difluorotioacetamida-oxazolidinonas como agentes antibacterianos y terapias antimicrobianas combinadas para combatir enfermedades infecciosas causadas por bacterias gram positivas y gram negativas. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del compuesto en donde R es -CH2- o CH2CH2-; R2 y R3 son independientemente -H o -F; X es -N- o -CH; Y es -SO-, -SO2-, o -SONR4-; y R4 es -H o -C1-4alquilo.
ARP030102259A 2002-06-28 2003-06-24 Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas AR039727A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39221302P 2002-06-28 2002-06-28

Publications (1)

Publication Number Publication Date
AR039727A1 true AR039727A1 (es) 2005-03-09

Family

ID=30000829

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030102259A AR039727A1 (es) 2002-06-28 2003-06-24 Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas

Country Status (10)

Country Link
US (1) US6927229B2 (es)
EP (1) EP1519924A1 (es)
JP (1) JP2005533818A (es)
AR (1) AR039727A1 (es)
AU (1) AU2003239581A1 (es)
BR (1) BR0312211A (es)
CA (1) CA2489411A1 (es)
MX (1) MXPA05000027A (es)
TW (1) TW200403240A (es)
WO (1) WO2004002967A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716493B2 (en) * 1995-09-01 2000-02-24 Pharmacia & Upjohn Company Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
WO2006056875A1 (en) * 2004-11-29 2006-06-01 Pharmacia & Upjohn Company Llc Thiazepine oxazolidinones as antibacterial agents
DK1899331T3 (da) 2005-06-29 2010-03-08 Pharmacia & Upjohn Co Llc Homomorpholinoxazolidnoner som antibakterielle midler
EP2009012B1 (en) 2006-03-31 2014-06-25 Research Foundation Itsuu Laboratory Novel compound having heterocyclic ring
WO2008069619A1 (en) * 2006-12-08 2008-06-12 Legochem Bioscience Ltd. Novel oxazolidinone derivatives, process for preparing thereof and pharmaceutical composition containing the same
EP2018864A1 (en) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
EA037643B1 (ru) * 2015-07-17 2021-04-26 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Замещенные фенилоксазолидиноны для антимикробной терапии
JP2019529522A (ja) 2016-10-10 2019-10-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子としての三環式スルホン類
CN110721153A (zh) * 2019-10-08 2020-01-24 四川太平洋药业有限责任公司 一种盐酸莫西沙星氯化钠注射液及制备工艺
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716493B2 (en) * 1995-09-01 2000-02-24 Pharmacia & Upjohn Company Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
US6255304B1 (en) * 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
UA66401C2 (en) * 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
BR0016605A (pt) 1999-12-21 2003-02-25 Upjohn Co Oxazolidinonas possuindo uma funcionalidade sulfoximina e seus usos como agente antimicrobiano
US20010047004A1 (en) 2000-02-10 2001-11-29 Hester Jackson B. Oxazolidinone thioamides with piperazine amide substituents
PE20020044A1 (es) 2000-06-16 2002-01-30 Upjohn Co Tiazina oxazolidinona

Also Published As

Publication number Publication date
US6927229B2 (en) 2005-08-09
JP2005533818A (ja) 2005-11-10
AU2003239581A1 (en) 2004-01-19
US20040077626A1 (en) 2004-04-22
BR0312211A (pt) 2007-05-29
TW200403240A (en) 2004-03-01
MXPA05000027A (es) 2005-08-26
CA2489411A1 (en) 2004-01-08
EP1519924A1 (en) 2005-04-06
WO2004002967A1 (en) 2004-01-08

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