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AR039197A1 - Sintesis de compuestos de piperidina y piperazina como antagonistas de ccr5 - Google Patents

Sintesis de compuestos de piperidina y piperazina como antagonistas de ccr5

Info

Publication number
AR039197A1
AR039197A1 ARP030101110A ARP030101110A AR039197A1 AR 039197 A1 AR039197 A1 AR 039197A1 AR P030101110 A ARP030101110 A AR P030101110A AR P030101110 A ARP030101110 A AR P030101110A AR 039197 A1 AR039197 A1 AR 039197A1
Authority
AR
Argentina
Prior art keywords
formula
compound
piperidine
ccg5
antagonists
Prior art date
Application number
ARP030101110A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR039197A1 publication Critical patent/AR039197A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Reivindicación 1: Un proceso para preparar una piperidina de fórmula (1) comprendiendo dicho proceso: (a) hacer reaccionar un compuesto de fórmula (2) con una base para liberar la base libre de la fórmula (3), (b) hacer reaccionar el compuesto de fórmula (3) con el compuesto de fórmula (4) y un compuesto de cianuración, para preparar el compuesto de fórmula (5), y c) hacer reaccionar el compuesto de fórmula (5) con un metal-metilo y un reactivo organometálico para dar el compuesto de fórmula (1)
ARP030101110A 2002-03-29 2003-03-28 Sintesis de compuestos de piperidina y piperazina como antagonistas de ccr5 AR039197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36874902P 2002-03-29 2002-03-29

Publications (1)

Publication Number Publication Date
AR039197A1 true AR039197A1 (es) 2005-02-09

Family

ID=28791902

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101110A AR039197A1 (es) 2002-03-29 2003-03-28 Sintesis de compuestos de piperidina y piperazina como antagonistas de ccr5

Country Status (10)

Country Link
US (2) US6992189B2 (es)
EP (1) EP1490352A1 (es)
JP (1) JP4538237B2 (es)
CN (2) CN101139343A (es)
AR (1) AR039197A1 (es)
AU (1) AU2003224777A1 (es)
CA (1) CA2480482A1 (es)
MX (1) MXPA04009428A (es)
WO (1) WO2003084950A1 (es)
ZA (1) ZA200406546B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA015517B1 (ru) 2004-04-13 2011-08-30 Инсайт Корпорейшн Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора
EP1819335A1 (en) * 2004-12-01 2007-08-22 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and sch-417690
JP4728350B2 (ja) * 2005-01-06 2011-07-20 シェーリング コーポレイション ケトンアミドの調製
US8367674B2 (en) 2008-04-17 2013-02-05 Concert Pharmaceuticals, Inc. Piperazine derivatives
CN101768139B (zh) * 2010-01-15 2011-11-30 浙江大学 哌嗪类衍生物及制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20013940A3 (cs) * 1999-05-04 2002-04-17 Schering Corporation Piperazinové deriváty uľitečné jako CCR5 antagonisté
US6391865B1 (en) * 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
EP1659111A3 (en) 1999-05-04 2007-05-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists
FR2821081B1 (fr) * 2001-02-16 2003-04-11 Rhodia Eng Plastics Srl Composition polymere thermoplastique a base de polyamide
US6649692B2 (en) * 2001-02-20 2003-11-18 Crompton Corporation Organopolysiloxane composition, emulsion-forming concentrates and aqueous emulsions formed therefrom and use of the emulsions in the treatment of textiles
US6818773B2 (en) * 2001-10-15 2004-11-16 Schering Corporation Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine
JP2005511693A (ja) * 2001-11-29 2005-04-28 シェーリング　コーポレイション 回転異性体の薬学的に活性な塩の量が増加した組成物の調製のためのプロセス
JP4728350B2 (ja) * 2005-01-06 2011-07-20 シェーリング コーポレイション ケトンアミドの調製

Also Published As

Publication number Publication date
US6992189B2 (en) 2006-01-31
WO2003084950A1 (en) 2003-10-16
CN1642943A (zh) 2005-07-20
CA2480482A1 (en) 2003-10-16
ZA200406546B (en) 2005-09-19
JP4538237B2 (ja) 2010-09-08
MXPA04009428A (es) 2005-01-25
CN100396676C (zh) 2008-06-25
CN101139343A (zh) 2008-03-12
JP2005521743A (ja) 2005-07-21
AU2003224777A1 (en) 2003-10-20
US20050187248A1 (en) 2005-08-25
EP1490352A1 (en) 2004-12-29
US20040024217A1 (en) 2004-02-05

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