AR024306A1 - Preparacion farmaceutica que contiene una neurotoxina botulinica. - Google Patents
Preparacion farmaceutica que contiene una neurotoxina botulinica.Info
- Publication number
- AR024306A1 AR024306A1 ARP000102818A ARP000102818A AR024306A1 AR 024306 A1 AR024306 A1 AR 024306A1 AR P000102818 A ARP000102818 A AR P000102818A AR P000102818 A ARP000102818 A AR P000102818A AR 024306 A1 AR024306 A1 AR 024306A1
- Authority
- AR
- Argentina
- Prior art keywords
- neurotoxin
- pharmaceutical preparation
- preparation containing
- botulinic
- neurotoxins
- Prior art date
Links
- 239000002581 neurotoxin Substances 0.000 title abstract 5
- 231100000618 neurotoxin Toxicity 0.000 title abstract 5
- 101710138657 Neurotoxin Proteins 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 108030001720 Bontoxilysin Proteins 0.000 abstract 2
- 231100001103 botulinum neurotoxin Toxicity 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000193155 Clostridium botulinum Species 0.000 abstract 1
- 230000000536 complexating effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Preparacion farmacéutica que contiene una de las neurotoxinas botulínicas de Clostridium Botulinum de los tipos A, B, C, D, E, F o G o una mezcla de dos omás de estas neurotoxinas, caracterizada porque la neurotoxina, o bien la mezcla de neurotoxinaestá libre de proteínas complejizantes que junto con lasneurotoxinas forman de manera natural los complejos de neurotoxina botulínica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19925739A DE19925739A1 (de) | 1999-06-07 | 1999-06-07 | Therapeutikum mit einem Botulinum-Neurotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024306A1 true AR024306A1 (es) | 2002-09-25 |
Family
ID=7910318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000102818A AR024306A1 (es) | 1999-06-07 | 2000-06-07 | Preparacion farmaceutica que contiene una neurotoxina botulinica. |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7964199B1 (es) |
| EP (1) | EP1185291B2 (es) |
| JP (2) | JP2003505343A (es) |
| KR (1) | KR100466407B1 (es) |
| CN (2) | CN101062009A (es) |
| AR (1) | AR024306A1 (es) |
| AT (1) | ATE258803T1 (es) |
| AU (1) | AU774590B2 (es) |
| CA (1) | CA2376193C (es) |
| CO (1) | CO5170431A1 (es) |
| CZ (1) | CZ20014351A3 (es) |
| DE (3) | DE19925739A1 (es) |
| DK (1) | DK1185291T3 (es) |
| EA (1) | EA004202B1 (es) |
| ES (1) | ES2215056T5 (es) |
| GE (1) | GEP20043200B (es) |
| HU (1) | HUP0201530A3 (es) |
| IL (2) | IL146974A0 (es) |
| MX (1) | MXPA01012540A (es) |
| NO (1) | NO20015964L (es) |
| PL (1) | PL198958B1 (es) |
| PT (1) | PT1185291E (es) |
| TW (1) | TWI251492B (es) |
| UA (1) | UA72253C2 (es) |
| WO (1) | WO2000074703A2 (es) |
| ZA (1) | ZA200110074B (es) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US20080038274A1 (en) | 1999-09-23 | 2008-02-14 | Foster Keith A | Inhibition of secretion from non-neuronal cells |
| US7838007B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating mammary gland disorders |
| US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
| US6821520B2 (en) | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
| JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
| US6688311B2 (en) | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
| US7140371B2 (en) | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
| EP1491205A4 (en) * | 2002-03-29 | 2007-04-25 | Chemo Sero Therapeut Res Inst | MEANS FOR THE TREATMENT OF HYPERMYOTONIA |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| US20120114697A1 (en) | 2002-08-19 | 2012-05-10 | Ira Sanders | Treatment of holocrine gland dysfunction with clostridia neurotoxins |
| AU2003263860A1 (en) * | 2002-08-19 | 2004-03-03 | Ira Sanders | Treatment of holocrine gland dysfunction with clostridia neurotoxins |
| US7824693B2 (en) | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
| US8071550B2 (en) | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
| BRPI0408131A (pt) * | 2003-03-06 | 2006-03-01 | Botulinum Toxin Res Ass Inc | tratamento com toxina botulina de dor facial e cefaléia crÈnicas relacionadas com sinusite |
| US6838434B2 (en) * | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
| WO2004112821A1 (ja) * | 2003-06-20 | 2004-12-29 | Santen Pharmaceutical Co., Ltd. | 筋緊張亢進性疾患の治療剤 |
| US6974579B2 (en) * | 2004-01-08 | 2005-12-13 | Allergan, Inc. | Methods for treating vascular disorders |
| US8974774B2 (en) | 2004-03-03 | 2015-03-10 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| CA2558408C (en) | 2004-03-03 | 2014-11-18 | Essentia Biosystems, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| CN101005853B (zh) * | 2004-07-26 | 2011-05-04 | 莫茨药物股份两合公司 | 包含肉毒杆菌神经毒素的治疗组合物 |
| US7429386B2 (en) | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
| US7179474B2 (en) | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
| EP1799254A1 (en) * | 2004-09-27 | 2007-06-27 | Merz Pharma GmbH & Co.KGaA | Clostridial neurotoxins for use in tissue healing |
| MXPA06009853A (es) * | 2005-03-03 | 2007-03-29 | Allergan Inc | Medios para bacteria de clostridium y procesos para obtener una toxina clostridial. |
| MX2007010673A (es) | 2005-03-03 | 2008-04-07 | Revance Therapeutics Inc | Composiciones y metodos para la aplicacion topica y el suministro transdermico de toxinas botulinicas. |
| US7419675B2 (en) | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
| WO2006133818A1 (de) * | 2005-06-17 | 2006-12-21 | Merz Pharma Gmbh & Co. Kgaa | Vorrichtung und verfahren zur fermentativen herstellung biologisch wirksamer verbindungen |
| US8518414B2 (en) | 2005-11-17 | 2013-08-27 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
| EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
| AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| US10792344B2 (en) | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
| EP2048156A1 (en) * | 2007-10-12 | 2009-04-15 | Merz Pharma GmbH & Co.KGaA | Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin |
| JP2010528999A (ja) | 2007-06-01 | 2010-08-26 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | ボツリヌストキシンの神経毒成分に基づいた、温度安定な筋弛緩薬を固体形態で供給する方法 |
| DE102007038015A1 (de) * | 2007-08-10 | 2009-02-19 | Hefter, Harald, Prof. Dr. med. Dr. rer. nat. | Verwendung eines Neurotoxins |
| US9161970B2 (en) * | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
| EP2072057A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury |
| EP2072039A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
| US8540987B2 (en) * | 2008-01-29 | 2013-09-24 | Institute For Antibodies Co., Ltd. | Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody |
| US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| CN102356091A (zh) * | 2008-03-14 | 2012-02-15 | 阿勒根公司 | 基于免疫的血清型a肉毒杆菌毒素活性测定 |
| JPWO2009123174A1 (ja) * | 2008-03-31 | 2011-07-28 | 一般財団法人化学及血清療法研究所 | A2型ボツリヌス神経毒素製剤 |
| AU2009286973B2 (en) | 2008-08-29 | 2014-06-12 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins with altered persistency |
| ES2426667T3 (es) | 2008-09-09 | 2013-10-24 | Susanne Grafe | Toxina botulínica para introducir infertilidad temporal en un vertebrado (por ejemplo, un ser humano) |
| CN101386648B (zh) * | 2008-09-25 | 2012-05-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途 |
| CA2745657C (en) | 2008-12-04 | 2022-06-21 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| JP2011074025A (ja) * | 2009-09-30 | 2011-04-14 | Chemo-Sero-Therapeutic Research Inst | ボツリヌス毒素の精製方法 |
| PT2490986T (pt) * | 2009-10-21 | 2018-11-13 | Revance Therapeutics Inc | Métodos e sistemas para purificar neurotoxina botulínica não complexada |
| KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| ES2639617T3 (es) | 2010-10-12 | 2017-10-27 | Merz Pharma Gmbh & Co. Kgaa | Formulación adecuada para estabilizar proteínas, que carece de excipientes de mamíferos |
| AU2012276512B2 (en) * | 2011-06-27 | 2016-04-21 | Sang Duck Kim | Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same |
| US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
| AU2014298922B2 (en) * | 2013-07-30 | 2018-03-15 | Merz Pharma Gmbh & Co. Kgaa | Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof |
| US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| EP3285800B1 (en) * | 2015-04-24 | 2019-09-18 | Consiglio Nazionale Delle Ricerche | A new therapeutic use of the botulinum neurotoxin serotype a |
| KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
| KR102463881B1 (ko) * | 2016-10-04 | 2022-11-07 | (주)메디톡스 | 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법 |
| JP7604222B2 (ja) | 2017-03-22 | 2024-12-23 | ボンチ インコーポレイテッド | 治療用のボツリヌス神経毒素 |
| JP7007392B2 (ja) | 2017-03-24 | 2022-01-24 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 唾液腺炎の治療におけるボツリヌス神経毒素の改善された使用 |
| WO2020047159A1 (en) | 2018-08-28 | 2020-03-05 | Ira Sanders | Skin therapeutics |
| EP3860640A1 (en) | 2018-10-02 | 2021-08-11 | Merz Pharma GmbH & Co. KGaA | Novel uses of botulinum neurotoxin for treating lipoedema |
| BR112021015480A2 (pt) | 2019-02-21 | 2021-10-05 | Merz Pharma Gmbh & Co. Kgaa | Usos inovadores de neurotoxina botulínica para o tratamento contra tremor |
| IL298399A (en) | 2020-06-05 | 2023-01-01 | Merz Pharma Gmbh & Co Kgaa | Treatment of facial wrinkles with the botulinum toxin in high dose and low volume |
| KR102724651B1 (ko) * | 2021-07-08 | 2024-11-01 | 주식회사 파마리서치바이오 | 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법 |
| TW202400122A (zh) | 2022-02-28 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素用於降低皮膚毛孔尺寸及/或皮脂產生之用途、以及降低皮膚毛孔尺寸及/或皮脂產生的方法 |
| WO2024115413A1 (en) | 2022-11-28 | 2024-06-06 | Merz Pharma Gmbh & Co. Kgaa | High concentration botulinum toxin treatment for neck rejuvenation |
| AR131172A1 (es) | 2022-11-28 | 2025-02-19 | Merz Pharma Gmbh & Co Kgaa | Inyección de toxina botulínica en el platisma para el rejuvenecimiento del rostro inferior y del cuello |
| WO2024194181A1 (en) | 2023-03-20 | 2024-09-26 | Merz Therapeutics GmbH | Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient |
| TW202515602A (zh) | 2023-05-23 | 2025-04-16 | 德商梅茲治療有限公司 | 用於治療周邊神經病變性疼痛的肉毒桿菌毒素 |
| WO2025012403A1 (en) | 2023-07-12 | 2025-01-16 | Merz Pharma Gmbh & Co. Kgaa | Treatment of hyperpigmentation conditions by botulinum toxin |
| WO2025228877A1 (en) | 2024-04-29 | 2025-11-06 | Merz Therapeutics GmbH | Botulinum toxin for the preventive treatment of migraine |
| WO2026021713A1 (en) | 2024-07-23 | 2026-01-29 | Merz Therapeutics GmbH | Uses of magnetic nerve stimulation associated with botulinum neurotoxin administration |
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| ATE286405T1 (de) | 1993-05-14 | 2005-01-15 | Stephen S Arnon | Verfahren zur verhütung der nebenwirkungen und unempfindlichkeit gegenüber therapeutischen verwendungen von toxinen |
| AU683275B2 (en) | 1993-06-10 | 1997-11-06 | Allergan, Inc. | Multiple botulinum toxins for treating neuromuscular disorders and conditions |
| DE69434319T3 (de) | 1993-12-28 | 2011-02-17 | Allergan, Inc., Irvine | Botulinustoxine A oder B zur Behandlung von Schmerzen verbunden mit Glattmuskelkrämpfen |
| US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| AU2431995A (en) | 1994-05-09 | 1995-11-29 | William J. Binder | Method for reduction of headache pain |
| AU2907695A (en) | 1994-08-08 | 1996-03-07 | Wisconsin Alumni Research Foundation | Purification and pharmaceutical compositions containing type g botulinum neurotoxin |
| US5756468A (en) * | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
| US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| ATE239491T1 (de) * | 1995-06-06 | 2003-05-15 | L Bruce Pearce | Verbesserte zusammensetzungen und verfahren zur chemodenervation mit neurotoxinen |
| US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
| DK2145629T3 (da) * | 1997-07-15 | 2012-05-29 | Univ Colorado Regents | Anvendelse af neurotoksinterapi til behandling af urologiske og relaterede sygdomme |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| DE19856897A1 (de) * | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
| DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US6358917B1 (en) * | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
| US6787517B1 (en) * | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| KR101818895B1 (ko) * | 2009-07-02 | 2018-01-15 | 메르츠 파마 게엠베하 운트 코. 카가아 | 생물학적 활성이 감소된 신경독 |
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1999
- 1999-06-07 DE DE19925739A patent/DE19925739A1/de not_active Withdrawn
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2000
- 2000-05-26 JP JP2001501237A patent/JP2003505343A/ja active Pending
- 2000-05-26 DK DK00943666T patent/DK1185291T3/da active
- 2000-05-26 GE GEAP20006278A patent/GEP20043200B/en unknown
- 2000-05-26 MX MXPA01012540A patent/MXPA01012540A/es active IP Right Grant
- 2000-05-26 EP EP00943666A patent/EP1185291B2/de not_active Expired - Lifetime
- 2000-05-26 CA CA002376193A patent/CA2376193C/en not_active Expired - Fee Related
- 2000-05-26 ES ES00943666T patent/ES2215056T5/es not_active Expired - Lifetime
- 2000-05-26 AU AU58047/00A patent/AU774590B2/en not_active Ceased
- 2000-05-26 EA EA200200017A patent/EA004202B1/ru not_active IP Right Cessation
- 2000-05-26 HU HU0201530A patent/HUP0201530A3/hu unknown
- 2000-05-26 US US10/018,373 patent/US7964199B1/en not_active Expired - Lifetime
- 2000-05-26 CN CNA2007101102394A patent/CN101062009A/zh active Pending
- 2000-05-26 CN CNB008086419A patent/CN100389820C/zh not_active Expired - Fee Related
- 2000-05-26 DE DE50005208T patent/DE50005208D1/de not_active Expired - Lifetime
- 2000-05-26 UA UA2002010181A patent/UA72253C2/uk unknown
- 2000-05-26 CZ CZ20014351A patent/CZ20014351A3/cs unknown
- 2000-05-26 PL PL352468A patent/PL198958B1/pl not_active IP Right Cessation
- 2000-05-26 IL IL14697400A patent/IL146974A0/xx active IP Right Grant
- 2000-05-26 PT PT00943666T patent/PT1185291E/pt unknown
- 2000-05-26 KR KR10-2001-7015668A patent/KR100466407B1/ko not_active Expired - Fee Related
- 2000-05-26 AT AT00943666T patent/ATE258803T1/de active
- 2000-05-26 WO PCT/DE2000/001777 patent/WO2000074703A2/de not_active Ceased
- 2000-05-26 DE DE10081516T patent/DE10081516D2/de not_active Ceased
- 2000-06-07 AR ARP000102818A patent/AR024306A1/es unknown
- 2000-06-07 CO CO00042309A patent/CO5170431A1/es not_active Application Discontinuation
- 2000-08-24 TW TW089111212A patent/TWI251492B/zh not_active IP Right Cessation
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2001
- 2001-12-06 ZA ZA200110074A patent/ZA200110074B/xx unknown
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- 2001-12-06 IL IL146974A patent/IL146974A/en not_active IP Right Cessation
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2007
- 2007-05-16 JP JP2007130686A patent/JP2007238627A/ja not_active Withdrawn
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2011
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