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NL2031339A - Antibacterial coating formed by copolymerization of chlorhexidine and catecholamine as well as preparation method and application thereof - Google Patents

Antibacterial coating formed by copolymerization of chlorhexidine and catecholamine as well as preparation method and application thereof Download PDF

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Publication number
NL2031339A
NL2031339A NL2031339A NL2031339A NL2031339A NL 2031339 A NL2031339 A NL 2031339A NL 2031339 A NL2031339 A NL 2031339A NL 2031339 A NL2031339 A NL 2031339A NL 2031339 A NL2031339 A NL 2031339A
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NL
Netherlands
Prior art keywords
chlorhexidine
antibacterial
catecholamine
coating
antibacterial coating
Prior art date
Application number
NL2031339A
Other languages
English (en)
Other versions
NL2031339B1 (en
Inventor
Li Xiangyang
Original Assignee
Univ Anhui Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Anhui Medical filed Critical Univ Anhui Medical
Publication of NL2031339A publication Critical patent/NL2031339A/en
Application granted granted Critical
Publication of NL2031339B1 publication Critical patent/NL2031339B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Claims (6)

CONCLUSIES
1. Antibacteriële coating gevormd door copolymerisatie van chloor- hexidine en catecholamine, waarbij de antibacteriële coating wordt gevormd in een proces waarbij chloorhexidine en catecholamine wor- den onderworpen aan zelf-assemblage om nanodeeltjes te vormen en de nanodeeltjes hechten aan oppervlakken van een verscheidenheid aan substraten om een compacte gepolymeriseerde coating te vormen.
2. Werkwijze voor het bereiden van de antibacteriële coating vol- gens conclusie 1, omvattende de volgende stappen: Sl: het bereiden van een waterige catecholamine-oplossing van een bepaalde concentratie en een chloorhexidine-oplossing van een be- paalde concentratie; S2: het langzaam druppelen van de chloorhexidine-oplossing die is bereid in S1 in de waterige catecholamine-oplossing, en toestaan dat catecholamine en chloorhexidine volledig worden gepolymeri- seerd; en S3: het mengsel 24 uur stil laten staan om een met chloorhexidine en catecholamine gepolymeriseerde coating op een substraat af te zetten.
3. Werkwijze voor het bereiden van de antibacteriële coating vol- gens conclusie 2, waarbij het catecholamine dopamine, noradrenali- ne, looizuur, galluszuur, bruine algenpolyfenol of epigallocate- chinegallaat is.
4. Werkwijze voor het bereiden van de antibacteriële coating vol- gens conclusie 3, waarbij in S1 een concentratie van de waterige polyfenoloplossing van bruine algen 0,25 mg/ml is en een concen- tratie van de chloorhexidine-oplossing 0,8 mg/ml is.
5. Werkwijze voor het bereiden van de antibacteriële coating vol- gens een van de conclusies 2 tot 4, waarbij een pH-waarde van een polymerisatieproces in S2 8,5 is.
6. Aanbrengen van de antibacteriële coating gevormd door copolyme- risatie van chloorhexidine en catecholamine volgens conclusie 1, waarbij de antibacteriële coating wordt aangebracht om antibacte- riële toepassingen, antibacteriële botmaterialen en antibacteriële tandheelkundige materialen te bereiden.
NL2031339A 2021-03-23 2022-03-21 Antibacterial coating formed by copolymerization of chlorhexidine and catecholamine as well as preparation method and application thereof NL2031339B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110309134.1A CN113244436B (zh) 2021-03-23 2021-03-23 一种氯己定和儿茶酚胺共聚合的抗菌涂层及其制备方法和应用

Publications (2)

Publication Number Publication Date
NL2031339A true NL2031339A (en) 2022-09-28
NL2031339B1 NL2031339B1 (en) 2023-01-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NL2031339A NL2031339B1 (en) 2021-03-23 2022-03-21 Antibacterial coating formed by copolymerization of chlorhexidine and catecholamine as well as preparation method and application thereof

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CN (1) CN113244436B (nl)
NL (1) NL2031339B1 (nl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115554480A (zh) * 2022-09-23 2023-01-03 安徽医科大学 用于骨和牙体表面抗菌的纳米涂敷材料及其制备方法
CN116585539B (zh) * 2023-03-09 2025-10-17 安徽医科大学 一种多酚涂层、其制备方法及应用
CN117653558A (zh) * 2023-10-30 2024-03-08 安徽医科大学 一种牙本质小管快速封堵络合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5894017A (en) * 1997-06-06 1999-04-13 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
CN106880876A (zh) * 2017-02-24 2017-06-23 创领心律管理医疗器械（上海）有限公司 一种植入性医疗器械的抗菌涂层的制备方法
CN108815587B (zh) * 2018-07-05 2020-07-21 四川大学 一种具有长期抗菌功能的水凝胶涂层及其制备方法
CN109778350B (zh) * 2019-01-09 2021-07-27 三峡大学 一种含氯己定类抗菌药物的藻酸盐纤维制备方法及应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALVES DIANA ET AL: "Tailoring the immobilization and release of chlorhexidine using dopamine chemistry to fight infections associated to orthopedic devices", MATERIALS SCIENCE AND ENGINEERING C, ELSEVIER SCIENCE S.A, CH, vol. 120, 20 November 2020 (2020-11-20), XP086478761, ISSN: 0928-4931, [retrieved on 20201120], DOI: 10.1016/J.MSEC.2020.111742 *

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Publication number Publication date
NL2031339B1 (en) 2023-01-31
CN113244436A (zh) 2021-08-13
CN113244436B (zh) 2022-07-19

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Effective date: 20250401