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MXPA04010860A - Composiciones terapeuticas de 1,2,3,6-tetrahidropirimidin-2-ona y metodos para usarla. - Google Patents

Composiciones terapeuticas de 1,2,3,6-tetrahidropirimidin-2-ona y metodos para usarla.

Info

Publication number
MXPA04010860A
MXPA04010860A MXPA04010860A MXPA04010860A MXPA04010860A MX PA04010860 A MXPA04010860 A MX PA04010860A MX PA04010860 A MXPA04010860 A MX PA04010860A MX PA04010860 A MXPA04010860 A MX PA04010860A MX PA04010860 A MXPA04010860 A MX PA04010860A
Authority
MX
Mexico
Prior art keywords
phenyl
tetrahydropyrimidine
therapeutic
trifluoromethyl
fluoro
Prior art date
Application number
MXPA04010860A
Other languages
English (en)
Inventor
T Wei Edward
Original Assignee
Cragmont Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/139,193 external-priority patent/US6919348B2/en
Application filed by Cragmont Pharmaceuticals Llc filed Critical Cragmont Pharmaceuticals Llc
Publication of MXPA04010860A publication Critical patent/MXPA04010860A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporciona una composicion terapeutica que comprende un agonista de receptor de frio de 1,2,3,6-tetrahidropirimidina-2-ona substituido con 1-R1-fenilo, 4-R2-fenilo en una cantidad efectiva terapeuticamente. La composicion ademas comprende preferentemente uno o mas farmacos activos farmaceuticamente tales como un glucocorticosteroide antiinflamatorio, un descongestionante de amina simpatomimetico, una antihistamina, un anestesico local, mentol o un analogo de mentol, un inmunosupresante, y mezclas de los mismos. El agonista de receptor de frio puede estar representado por la formula general (1) -[R1-fenil]-4-[R2-fenil]-1,2,3,6-tetrahidropirimidina-2-ona en donde: R1 es-hidroxi, --cloro, -fluoro, -alquilo, -acetoxi, -trifluorometilo; y R2 es -nitro, -cloro, -fluoro, -alquilo, - trifluurometilo. Las composiciones terapeuticas de la invencion producen enfriamiento y relajamiento de larga duracion, particularmente cuando se formula para suministro para suprimir las sensaciones de picor y dolor, tal como para suministro a piel inflamada, a las membranas mucosas de los parpados, de las areas anogenitales y de las vias respiratorias y a la mucosa enterica.
MXPA04010860A 2002-05-02 2003-04-28 Composiciones terapeuticas de 1,2,3,6-tetrahidropirimidin-2-ona y metodos para usarla. MXPA04010860A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/139,193 US6919348B2 (en) 2002-05-02 2002-05-02 Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith
US10/191,481 US20030207903A1 (en) 2002-05-02 2002-07-08 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for sexual disfunction
US10/233,126 US20030206873A1 (en) 2002-05-02 2002-08-29 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for gastrointestinal dysfunction
US10/232,798 US6743801B2 (en) 2002-05-02 2002-08-29 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for pain and inflammation
US10/267,896 US6933301B2 (en) 2002-05-02 2002-10-08 1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders
PCT/GB2003/001811 WO2003092697A1 (en) 2002-05-02 2003-04-28 Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith

Publications (1)

Publication Number Publication Date
MXPA04010860A true MXPA04010860A (es) 2005-11-17

Family

ID=29408146

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04010860A MXPA04010860A (es) 2002-05-02 2003-04-28 Composiciones terapeuticas de 1,2,3,6-tetrahidropirimidin-2-ona y metodos para usarla.

Country Status (8)

Country Link
EP (1) EP1503763B1 (es)
JP (1) JP4558479B2 (es)
CN (1) CN1665507B (es)
AU (1) AU2003222990B2 (es)
CA (1) CA2483090C (es)
IL (1) IL164887A0 (es)
MX (1) MXPA04010860A (es)
WO (1) WO2003092697A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0221697D0 (en) * 2002-09-18 2002-10-30 Unilever Plc Novel compouds and their uses
ES2476902T5 (es) * 2003-07-02 2018-04-03 Genentech, Inc. Compuestos activadores de TRP-P8 y métodos de tratamiento terapéuticos
WO2006131203A1 (en) * 2005-06-10 2006-12-14 Unilever N.V. Oral care composition comprising a 1 , 2 , 3 , 6-tetrahydropyrimidine-2-one cooling agent
FR2895260B1 (fr) * 2005-12-23 2009-02-20 Servier Lab Nouvelle composition pharmaceutique a base d'huile essentielle pour pulverisation nasale et/ou buccale
US7727516B2 (en) * 2006-02-28 2010-06-01 The Procter & Gamble Company Reduction of hair growth
GB0615136D0 (en) * 2006-07-29 2006-09-06 Univ Edinburgh Induction of analgesia in neuropathic pain
WO2008038126A2 (en) * 2006-09-29 2008-04-03 Infa S.A. Packaging system for pharmaceutical compositions and kit for intravenous administration
KR101049788B1 (ko) * 2011-01-28 2011-07-19 주식회사 에코덤 다양한 피부질환에서 소양증의 치유 또는 개선용 경피흡수제제
RU2590979C2 (ru) * 2011-02-11 2016-07-10 ЗедЭкс ФАРМА, ЭлЭлСи Составы l-ментола, состоящие из множества частиц, и связанные с ними способы
EP2497458A1 (en) 2011-03-08 2012-09-12 B.R.A.I.N. Biotechnology Research And Information Network AG Small molecule modulators of the cold and menthol receptor TRPM8
CN102178676B (zh) * 2011-04-29 2012-07-25 山东大学 一种治疗脑胶质瘤的药物组合物
DE102012218733A1 (de) * 2012-10-15 2014-04-17 Beiersdorf Ag Kosmetische oder dermatologische Zubereitung zur Prophylaxe und/oder Behandlung atopischer Dermatitis
JP7655568B2 (ja) * 2019-10-25 2025-04-02 ムココルト アクチエボラグ 粘膜又は皮膚における炎症状態の治療

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821221A (en) * 1970-08-25 1974-06-28 Delmar Chem 1,2,3,6-tetrahydropyrimidine-2-one compounds and processes for makingthem
GB1476351A (en) * 1974-04-17 1977-06-10 Wilkinson Sword Ltd Compounds having a physiological cooling effect and compo sitions containing them
JPS5310597A (en) * 1976-07-15 1978-01-31 Shiyoujirou Narumiya Slowly vertically dropping device
CA1306192C (en) * 1986-12-17 1992-08-11 Andrew Hamilton Ward Medicament containing a silicon derivative of menthol
JPH01185267A (ja) * 1988-01-19 1989-07-24 Geran Kaihatsu Kenkyusho:Kk 新吸入器
FR2777187B1 (fr) * 1998-04-14 2000-05-19 Yves Theodore Stephane Tillet Composition pour faciliter l'action du levomenthol sur les thermorecepteurs de la muqueuse congestionnee du vestibule nasal et la regeneration naturelle de cette muqueuse
US20020009478A1 (en) * 1998-08-24 2002-01-24 Douglas Joseph Dobrozsi Oral liquid mucoadhesive compositions
JP2002536069A (ja) * 1999-02-02 2002-10-29 エイボン プロダクツ インコーポレーテッド のぼせの不快感を軽減する方法およびそのための組成物

Also Published As

Publication number Publication date
CN1665507B (zh) 2010-05-26
EP1503763B1 (en) 2009-12-02
JP4558479B2 (ja) 2010-10-06
AU2003222990A1 (en) 2003-11-17
CA2483090C (en) 2011-01-25
CA2483090A1 (en) 2003-11-13
CN1665507A (zh) 2005-09-07
JP2005526841A (ja) 2005-09-08
WO2003092697A1 (en) 2003-11-13
AU2003222990B2 (en) 2009-11-12
EP1503763A1 (en) 2005-02-09
IL164887A0 (en) 2005-12-18

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