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MX2019005770A - Anticuerpos anti-met, moleculas de union a antigeno biespecificas que se unen a met y metodos de uso de los mismos. - Google Patents

Anticuerpos anti-met, moleculas de union a antigeno biespecificas que se unen a met y metodos de uso de los mismos.

Info

Publication number
MX2019005770A
MX2019005770A MX2019005770A MX2019005770A MX2019005770A MX 2019005770 A MX2019005770 A MX 2019005770A MX 2019005770 A MX2019005770 A MX 2019005770A MX 2019005770 A MX2019005770 A MX 2019005770A MX 2019005770 A MX2019005770 A MX 2019005770A
Authority
MX
Mexico
Prior art keywords
binding molecules
antigen
met
bispecific antigen
binding
Prior art date
Application number
MX2019005770A
Other languages
English (en)
Other versions
MX391786B (es
Inventor
Chen Gang
Macdonald Douglas
Daly Christopher
Babb Robert
Nittoli Thomas
Dasilva John
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2019005770A publication Critical patent/MX2019005770A/es
Publication of MX391786B publication Critical patent/MX391786B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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Abstract

En el presente documento se proporcionan anticuerpos y moléculas de unión a antígeno biespecíficas que se unen a MET y métodos de uso de los mismos. Las moléculas de unión a antígeno biespecíficas comprenden un primer y un segundo dominio de unión a antígeno, en donde el primer y el segundo dominio de unión a antígeno se unen a dos epítopos diferentes (preferiblemente no superpuestos) del dominio extracelular del MET humano. Las moléculas de unión a antígeno biespecíficas son capaces de bloquear la interacción entre MET humano y su ligando HGF. Las moléculas de unión a antígeno biespecíficas pueden exhibir una actividad agonista de MET mínima o nula, por ejemplo, en comparación con las moléculas de unión a antígeno monovalentes que comprenden solo uno de los dominios de unión a antígeno de la molécula biespecífica, los que tienden a ejercer una actividad agonista de MET no deseada. También se incluyen los conjugados anticuerpo-fármaco (ADC) que comprenden los anticuerpos o moléculas de unión a antígeno biespecíficas proporcionados en el presente documento enlazados a un agente citotóxico, radionúclido u otro resto, así como a métodos para tratar el cáncer en un sujeto mediante la administración al sujeto de una molécula de unión a antígeno biespecífica o un ADC de la misma.
MX2019005770A 2016-11-16 2017-11-15 Anticuerpos anti-met, moleculas de unión a antígeno biespecificas que se unen a met y métodos de uso de los mismos. MX391786B (es)

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