MX2016017240A - Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y metodos de uso de los mismos. - Google Patents
Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y metodos de uso de los mismos.Info
- Publication number
- MX2016017240A MX2016017240A MX2016017240A MX2016017240A MX2016017240A MX 2016017240 A MX2016017240 A MX 2016017240A MX 2016017240 A MX2016017240 A MX 2016017240A MX 2016017240 A MX2016017240 A MX 2016017240A MX 2016017240 A MX2016017240 A MX 2016017240A
- Authority
- MX
- Mexico
- Prior art keywords
- lag
- diabodies
- specific
- immunospecific
- directed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se dirige a un diacuerpo bi-específico que comprende dos o más cadenas de polipéptidos y que poseen al menos un Sitio de Unión de Epítopo que es inmunoespecífico para un epítopo de PD-1 y al menos un Sitio de Unión de Epítopo que es inmunoespecífico para un epítopo de LAG-3 (es decir, un ``diacuerpo bi-específico de PD-1 x LAG-3´´). De mayor preferencia, la presente invención se dirige a diacuerpos bi-específicos que comprenden cuatro cadenas de polipéptidos y que poseen dos Sitios de Unión de Epítopo que son inmunoespecíficos para un (o dos) epítopos de PD- 1 y dos Sitio de Unión de Epítopo que son inmunoespecíficos para uno (o dos) epítopos de LAG-3 (es decir, un ``diacuerpo tetravalente bi-específico de PD-1 x LAG-3´´). La presente invención también se dirige a tales diacuerpos que comprenden adicionalmente un Dominio de Fc de inmunoglobulina (``diacuerpos de Fc bi-específicos y diacuerpos de Fc tetravalentes bi-específicos´´). Los diacuerpos de la presente invención son capaces de unirse simultáneamente a PD-1 y a LAG-3, particularmente cuando tales moléculas se disponen sobre las superficies de las células humanas. La invención se dirige a composiciones farmacéuticas que contienen tales diacuerpos, y a métodos que implican el uso de tales diacuerpos en el tratamiento de cáncer y otras enfermedades y padecimientos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462017467P | 2014-06-26 | 2014-06-26 | |
| PCT/US2015/036634 WO2015200119A1 (en) | 2014-06-26 | 2015-06-19 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016017240A true MX2016017240A (es) | 2017-04-10 |
| MX369486B MX369486B (es) | 2019-11-11 |
Family
ID=54938685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016017240A MX369486B (es) | 2014-06-26 | 2015-06-19 | Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y métodos de uso de los mismos. |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US10160806B2 (es) |
| EP (1) | EP3161004B1 (es) |
| JP (2) | JP6890421B2 (es) |
| KR (1) | KR102514330B1 (es) |
| CN (1) | CN106715470B (es) |
| AR (1) | AR101009A1 (es) |
| AU (1) | AU2015280392B2 (es) |
| CA (1) | CA2953818C (es) |
| CL (1) | CL2016003335A1 (es) |
| CR (1) | CR20160599A (es) |
| CY (1) | CY1123917T1 (es) |
| DK (1) | DK3161004T3 (es) |
| EA (1) | EA036737B1 (es) |
| EC (1) | ECSP16096342A (es) |
| ES (1) | ES2843269T3 (es) |
| GE (2) | GEP20197034B (es) |
| HR (1) | HRP20210041T1 (es) |
| HU (1) | HUE052615T2 (es) |
| IL (1) | IL249764B (es) |
| LT (1) | LT3161004T (es) |
| MX (1) | MX369486B (es) |
| MY (1) | MY177324A (es) |
| PE (1) | PE20170767A1 (es) |
| PH (1) | PH12016502590B1 (es) |
| PL (1) | PL3161004T3 (es) |
| PT (1) | PT3161004T (es) |
| RS (1) | RS61284B1 (es) |
| SA (1) | SA516380600B1 (es) |
| SG (1) | SG11201610715SA (es) |
| SI (1) | SI3161004T1 (es) |
| SM (1) | SMT202100021T1 (es) |
| TW (1) | TWI693232B (es) |
| UA (1) | UA119673C2 (es) |
| WO (1) | WO2015200119A1 (es) |
| ZA (1) | ZA201608768B (es) |
Families Citing this family (210)
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| EP3180087B1 (en) | 2014-08-12 | 2019-03-13 | Alligator Bioscience AB | Combination therapies with anti cd40 antibodies |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
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| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
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