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MX2016003245A - Calreticulina mutante para la diagnosis de malignidades mieloides. - Google Patents

Calreticulina mutante para la diagnosis de malignidades mieloides.

Info

Publication number
MX2016003245A
MX2016003245A MX2016003245A MX2016003245A MX2016003245A MX 2016003245 A MX2016003245 A MX 2016003245A MX 2016003245 A MX2016003245 A MX 2016003245A MX 2016003245 A MX2016003245 A MX 2016003245A MX 2016003245 A MX2016003245 A MX 2016003245A
Authority
MX
Mexico
Prior art keywords
diagnosis
mutant calreticulin
mutant
sequences
calreticulin
Prior art date
Application number
MX2016003245A
Other languages
English (en)
Other versions
MX348980B (es
Inventor
Klampfl Thorsten
Gisslinger Heinz
Kralovics Robert
Original Assignee
Cemm-Forschungszentrum Für Molekulare Medizin Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51795161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016003245(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cemm-Forschungszentrum Für Molekulare Medizin Gmbh filed Critical Cemm-Forschungszentrum Für Molekulare Medizin Gmbh
Publication of MX2016003245A publication Critical patent/MX2016003245A/es
Publication of MX348980B publication Critical patent/MX348980B/es

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    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C07K2317/00—Immunoglobulins specific features
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • Pathology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para diagnosticar una malignidad mieloide que comprende determinar la presencia de un alelo mutante del gen de calreticulina. También las secuencias genómicas, secuencias de ADNc, secuencias de ARNm y secuencias de proteína de la calreticulina mutante son el objeto de la presente invención. Adicionalmente, la invención se refiere a usos médicos de inhibidores de calreticulina mutante.
MX2016003245A 2013-09-16 2014-09-15 Calreticulina mutante para la diagnosis de malignidades mieloides. MX348980B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13184632 2013-09-16
EP13186939 2013-10-01
US201361909313P 2013-11-26 2013-11-26
PCT/EP2014/069638 WO2015036599A1 (en) 2013-09-16 2014-09-15 Mutant calreticulin for the diagnosis of myeloid malignancies

Publications (2)

Publication Number Publication Date
MX2016003245A true MX2016003245A (es) 2016-09-13
MX348980B MX348980B (es) 2017-07-05

Family

ID=51795161

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016003245A MX348980B (es) 2013-09-16 2014-09-15 Calreticulina mutante para la diagnosis de malignidades mieloides.

Country Status (16)

Country Link
US (5) US10344335B2 (es)
EP (4) EP3494985B1 (es)
JP (2) JP6745220B2 (es)
KR (1) KR102433548B1 (es)
CN (2) CN105916876A (es)
AU (2) AU2014320262B2 (es)
BR (1) BR112016005611B1 (es)
CA (1) CA2924370C (es)
DK (3) DK3020727T4 (es)
ES (1) ES2577289T3 (es)
MX (1) MX348980B (es)
PL (2) PL3494985T3 (es)
PT (1) PT2808338E (es)
RU (1) RU2668808C2 (es)
SG (1) SG11201601193TA (es)
WO (1) WO2015036599A1 (es)

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WO2012088309A1 (en) 2010-12-21 2012-06-28 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic methods for manipulating phagocytosis through calreticulin and low density lipoprotein-related receptor
CN103091499B (zh) 2013-01-23 2015-07-08 三峡大学 一种肿瘤标志物钙网蛋白检测试剂盒的制备及应用
JP6745220B2 (ja) 2013-09-16 2020-08-26 ツェーエムエム−フォルシュングスツェントルム フュア モレクラレ メディツィン ゲーエムベーハー 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン

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RU2668808C2 (ru) 2018-10-02
CN113564254A (zh) 2021-10-29
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