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MX2013010737A - Novedosos metodos de purificacion de proteinas. - Google Patents

Novedosos metodos de purificacion de proteinas.

Info

Publication number
MX2013010737A
MX2013010737A MX2013010737A MX2013010737A MX2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A
Authority
MX
Mexico
Prior art keywords
surfactant
protein purification
purification methods
novel protein
protein
Prior art date
Application number
MX2013010737A
Other languages
English (en)
Inventor
Jun Liu
Arick Brown
Junyan Ji
Yuchang John Wang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46931857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013010737(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2013010737A publication Critical patent/MX2013010737A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14351—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona métodos para reducir incrustación de membranas de ultrafiltración en procesos en donde partículas de virus se retiran de soluciones acuosas que comprenden partículas de virus y por lo menos una proteína mediante la adición de un agente no iónico, surfactante o no surfactante a la solución acuosa antes de filtración. La invención también proporciona métodos para disociar agregados de proteína o para reducir la formación de agregados de proteína mediante la adición de un agente no iónico, surfactante o no surfactante a la solución de proteína.
MX2013010737A 2011-03-25 2012-03-23 Novedosos metodos de purificacion de proteinas. MX2013010737A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161467897P 2011-03-25 2011-03-25
PCT/US2012/030265 WO2012134987A1 (en) 2011-03-25 2012-03-23 Novel protein purification methods

Publications (1)

Publication Number Publication Date
MX2013010737A true MX2013010737A (es) 2014-03-12

Family

ID=46931857

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010737A MX2013010737A (es) 2011-03-25 2012-03-23 Novedosos metodos de purificacion de proteinas.

Country Status (17)

Country Link
US (1) US10906934B2 (es)
EP (1) EP2697369B1 (es)
KR (1) KR20140022845A (es)
CN (1) CN103582700B (es)
AU (1) AU2012237026A1 (es)
BR (1) BR112013024521A2 (es)
CA (1) CA2830640A1 (es)
ES (1) ES2685079T3 (es)
HR (1) HRP20181357T1 (es)
IL (1) IL228438A0 (es)
MX (1) MX2013010737A (es)
PL (1) PL2697369T3 (es)
RU (1) RU2013147609A (es)
SG (1) SG193564A1 (es)
SI (1) SI2697369T1 (es)
TR (1) TR201810703T4 (es)
WO (1) WO2012134987A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2518289C2 (ru) 2006-09-13 2014-06-10 Эббви Инк, Способ получения антитела или его фрагмента с подпиткой (варианты)
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TW201024318A (en) 2008-10-20 2010-07-01 Abbott Lab Isolation and purification of antibodies using protein A affinity chromatography
NZ592097A (en) 2008-10-20 2013-01-25 Abbott Lab Viral inactivation during purification of il-12 and il-18 antibodies
US10906934B2 (en) 2011-03-25 2021-02-02 Genentech, Inc. Protein purification methods
US8933009B2 (en) 2013-03-12 2015-01-13 Ecolab Usa Inc. Surfactant blends for cleaning filtration membranes
PL3068417T3 (pl) 2013-11-15 2024-05-13 F.Hoffmann-La Roche Ag Sposoby inaktywacji wirusów przy użyciu ekologicznych detergentów
EP3187582B1 (en) * 2014-08-27 2025-07-23 Godo Shusei Co., Ltd. Lactase solution
ES2975131T3 (es) * 2015-11-05 2024-07-03 Max Planck Gesellschaft Metodo para la separacion de composiciones virales que incluyen agotamiento y purificacion de las mismas
SG11201911877RA (en) 2017-06-12 2020-01-30 Asahi Kasei Medical Co Ltd Method for filtering protein-containing liquid
WO2019067173A1 (en) 2017-09-29 2019-04-04 Ecolab Usa Inc. USE OF EXTENSIVE SURFACTANTS IN CLEANING A TREATMENT MEMBRANE
CA3080656A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
WO2019160948A1 (en) 2018-02-14 2019-08-22 Ecolab Usa Inc. Compositions and methods for the reduction of biofilm and spores from membranes
EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
AU2020268896B2 (en) 2019-05-03 2024-11-28 F. Hoffmann-La Roche Ag Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform
WO2021118963A1 (en) * 2019-12-12 2021-06-17 Nutrition & Biosciences Usa 1, Llc Protein bioprocess
EP4178978A1 (en) * 2020-07-10 2023-05-17 Grifols Worldwide Operations Limited Method for obtaining a composition comprising human plasma-derived immunoglobulin m
CA3185567A1 (en) * 2020-07-15 2022-01-20 Nutrition & Biosciences Usa 1, Llc Bioprocess with reduced fouling on surfaces
AU2021371309A1 (en) 2020-10-30 2023-05-18 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
CN115779683B (zh) * 2022-12-16 2024-03-22 康日百奥生物科技(苏州)有限公司 除病毒过滤方法
US20250084125A1 (en) 2023-09-08 2025-03-13 Genentech, Inc. High viscosity ultrafiltration/diafiltration and single-pass tangential flow filtration processes

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4618533A (en) 1984-11-30 1986-10-21 Millipore Corporation Porous membrane having hydrophilic surface and process
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5017292A (en) * 1990-05-10 1991-05-21 Millipore Corporation Membrane, process and system for isolating virus from solution
WO1993011161A1 (en) 1991-11-25 1993-06-10 Enzon, Inc. Multivalent antigen-binding proteins
ATE198996T1 (de) 1994-07-28 2001-02-15 Millipore Corp Porösesverbundmembran und verfahren
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5888401A (en) 1996-09-16 1999-03-30 Union Camp Corporation Method and apparatus for reducing membrane fouling
US20070059302A1 (en) * 1997-04-07 2007-03-15 Genentech, Inc. Anti-vegf antibodies
US6096872A (en) 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
WO2002013859A1 (en) * 2000-08-10 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Method of inhibiting antibody-containing solution from coagulating or becoming turbid
CN1292655C (zh) 2001-11-08 2007-01-03 蛋白质设计实验室股份有限公司 IgG抗体稳定的液态药物制剂
AU2003212912A1 (en) * 2002-02-04 2003-09-02 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
EP2287201B1 (en) * 2002-03-01 2018-12-12 Immunomedics, Inc. RS7 antibodies
ES2282638T3 (es) * 2002-06-14 2007-10-16 Centocor, Inc. Uso de un modificador de clatrato para promover el paso de proteinas durante nanofiltracion.
CN1671741A (zh) * 2002-06-21 2005-09-21 拜奥根Idec公司 浓缩抗体的缓冲剂制剂及其使用方法
CA2496918A1 (en) 2002-08-28 2004-03-11 Introgen Therapeutics Inc. Chromatographic methods for adenovirus purification
AU2004294403A1 (en) 2003-12-01 2005-06-16 Novo Nordisk Health Care Ag Nanofiltration of factor VII solutions to remove virus
AU2005229674B2 (en) 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
GT200600031A (es) * 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
CA2602944C (en) * 2005-04-11 2015-08-11 Crucell Holland B.V. Virus purification using ultrafiltration
EP1886976A1 (en) 2006-08-09 2008-02-13 Thermphos Trading GmbH Method of scale inhibition
US8741600B2 (en) * 2007-06-19 2014-06-03 Asahi Kasei Kabushiki Kaisha Method for separation of immunoglobulin monomers
WO2010109920A1 (ja) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 高濃度モノクローナル抗体溶液中のウイルス除去方法
DK2462158T3 (en) * 2009-08-06 2018-03-05 Hoffmann La Roche Method to improve virus removal in protein purification
US10906934B2 (en) 2011-03-25 2021-02-02 Genentech, Inc. Protein purification methods

Also Published As

Publication number Publication date
AU2012237026A1 (en) 2013-10-24
CN103582700A (zh) 2014-02-12
EP2697369A1 (en) 2014-02-19
CN103582700B (zh) 2016-08-17
RU2013147609A (ru) 2015-04-27
US10906934B2 (en) 2021-02-02
KR20140022845A (ko) 2014-02-25
HK1194434A1 (zh) 2014-10-17
PL2697369T3 (pl) 2018-12-31
HRP20181357T1 (hr) 2018-10-19
SG193564A1 (en) 2013-10-30
EP2697369B1 (en) 2018-06-27
ES2685079T3 (es) 2018-10-05
CA2830640A1 (en) 2012-10-04
WO2012134987A1 (en) 2012-10-04
BR112013024521A2 (pt) 2019-09-24
EP2697369A4 (en) 2015-01-21
TR201810703T4 (tr) 2018-08-27
IL228438A0 (en) 2013-12-31
US20140309403A1 (en) 2014-10-16
SI2697369T1 (sl) 2018-10-30
NZ615579A (en) 2016-09-30

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