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MX2013008603A - Proceso para la preparacion de 4-amino-3-cloro-5-fluoro-6-picolina tos (sustituidos). - Google Patents

Proceso para la preparacion de 4-amino-3-cloro-5-fluoro-6-picolina tos (sustituidos).

Info

Publication number
MX2013008603A
MX2013008603A MX2013008603A MX2013008603A MX2013008603A MX 2013008603 A MX2013008603 A MX 2013008603A MX 2013008603 A MX2013008603 A MX 2013008603A MX 2013008603 A MX2013008603 A MX 2013008603A MX 2013008603 A MX2013008603 A MX 2013008603A
Authority
MX
Mexico
Prior art keywords
picolinates
fluoro
chloro
amino
preparation
Prior art date
Application number
MX2013008603A
Other languages
English (en)
Other versions
MX342328B (es
Inventor
Yuanming Zhu
James M Renga
Kim E Arndt
Gregory T Whiteker
Christian T Lowe
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of MX2013008603A publication Critical patent/MX2013008603A/es
Publication of MX342328B publication Critical patent/MX342328B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Los 4-amino-3-cloro-5-fluoro-6-picolinatos (sustituidos) se preparan de modo conveniente a partir de 3,4,5,6-tetracloropicolin onitrilo por medio de una serie de etapas que incluyen intercambio de flúor, aminación, intercambio de halógeno e hidrólisis, esterificación y acoplamiento asistido por metal de transición.
MX2013008603A 2011-01-25 2012-01-24 Proceso para la preparacion de 4-amino-3-cloro-5-fluoro-6-picolina tos (sustituidos). MX342328B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161435966P 2011-01-25 2011-01-25
PCT/US2012/022285 WO2012103041A2 (en) 2011-01-25 2012-01-24 Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates

Publications (2)

Publication Number Publication Date
MX2013008603A true MX2013008603A (es) 2013-08-12
MX342328B MX342328B (es) 2016-09-22

Family

ID=46544648

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008603A MX342328B (es) 2011-01-25 2012-01-24 Proceso para la preparacion de 4-amino-3-cloro-5-fluoro-6-picolina tos (sustituidos).

Country Status (20)

Country Link
US (3) US20120190857A1 (es)
EP (1) EP2668163B1 (es)
JP (1) JP5739018B2 (es)
KR (1) KR101537879B1 (es)
CN (2) CN103874685B (es)
AR (1) AR085022A1 (es)
AU (1) AU2012209277B2 (es)
BR (2) BR112013019025A2 (es)
CA (1) CA2825475C (es)
CO (1) CO6731125A2 (es)
HK (2) HK1199245A1 (es)
IL (1) IL227646A (es)
MX (1) MX342328B (es)
PL (1) PL2668163T3 (es)
RU (1) RU2545021C1 (es)
SG (1) SG192093A1 (es)
TW (1) TWI592401B (es)
UA (1) UA106945C2 (es)
WO (1) WO2012103041A2 (es)
ZA (1) ZA201305577B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI592401B (zh) 2011-01-25 2017-07-21 陶氏農業科學公司 用於製備４－胺基－３－氯－５－氟－６－（經取代的）吡啶甲酸酯的方法（一）
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
HUE041698T2 (hu) 2013-03-15 2019-05-28 Dow Agrosciences Llc Új 4-aminopiridin- és 6-aminopririmidin-karboxilátok mint herbicidek
US9113629B2 (en) 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
JP6543241B2 (ja) 2013-03-15 2019-07-10 ダウ アグロサイエンシィズ エルエルシー ４−アミノ−６−（複素環式）ピコリネートおよび６−アミノ−２−（複素環式）ピリミジン−４−カルボキシレートならびに除草剤としてのそれらの使用
TW201609651A (zh) 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（一）
TW201524956A (zh) * 2013-11-12 2015-07-01 Dow Agrosciences Llc 用於氟化化合物之過程（二）
TW201609652A (zh) 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（三）
TWI726900B (zh) 2015-08-04 2021-05-11 美商陶氏農業科學公司 用於氟化化合物之過程
AU2017268424B2 (en) 2016-05-19 2021-07-15 Corteva Agriscience Llc Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling
CN107954925A (zh) * 2016-10-18 2018-04-24 内蒙古佳瑞米精细化工有限公司 一种2,3-二氯-5-三氟甲基吡啶前杂的去除方法
CN113015721B (zh) 2018-09-19 2025-07-25 科迪华农业科技有限责任公司 毒莠定卤素类似物的制备
CN115298167A (zh) * 2020-03-18 2022-11-04 科迪华农业科技有限责任公司 6-芳基-4-氨基吡啶甲酸酯的改进合成
US20230357155A1 (en) * 2020-03-18 2023-11-09 Corteva Agriscience Llc Improved synthesis of 4-amino-6-(heterocyclic)picolinates

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3285925A (en) * 1962-03-06 1966-11-15 Dow Chemical Co Amino-trichloropicolinic acid compounds
US3803159A (en) * 1967-12-26 1974-04-09 Dow Chemical Co Fluorine containing cyanopyridines
US3629424A (en) * 1967-12-26 1971-12-21 Dow Chemical Co Cyanofluoropyridines and fungicidal compositions and methods for using the same
US4336384A (en) * 1981-04-23 1982-06-22 The Dow Chemical Company Preparation of 4-amino-3,5,6-trichloropicolinic acid
US5710106A (en) * 1996-02-22 1998-01-20 American Cyanamid Company Substituted pyridine herbicidal agents
FR2803592A1 (fr) * 2000-01-06 2001-07-13 Aventis Cropscience Sa Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant.
US6297197B1 (en) 2000-01-14 2001-10-02 Dow Agrosciences Llc 4-aminopicolinates and their use as herbicides
PT1246802E (pt) * 2000-01-14 2007-06-18 Dow Agrosciences Llc 4-aminopicolinatos e sua utilização como herbicidas.
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
UA82358C2 (uk) * 2003-04-02 2008-04-10 Дау Агросайенсиз Ллс 6-алкіл або алкеніл-4-амінопіколінати гербіцидна композиція, спосіб боротьби з небажаною рослинністю
RU2428416C2 (ru) * 2006-01-13 2011-09-10 Дау Агросайенсиз Ллс 6-(полизамещенный арил)-4-аминопиколинаты и их применение в качестве гербицидов
PL2193120T3 (pl) * 2007-10-02 2017-01-31 Dow Agrosciences Llc Kwasy 2'podstowione-6-amino-5-alkilo-, alkenylo- lub alkinylo-4-pirymidynokarboksylowe i kwasy 6-podstawione-4-amino-3-alkilo-, alkenylo- lub alkinylopikolinowe oraz ich zastosowanie jako herbicydy
US8252938B2 (en) * 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
GB0910766D0 (en) * 2009-06-22 2009-08-05 Syngenta Ltd Chemical compounds
GB201008290D0 (en) * 2010-05-18 2010-06-30 Syngenta Ltd Chemical compounds
TWI592401B (zh) 2011-01-25 2017-07-21 陶氏農業科學公司 用於製備４－胺基－３－氯－５－氟－６－（經取代的）吡啶甲酸酯的方法（一）

Also Published As

Publication number Publication date
CN103874685B (zh) 2016-02-03
CN103874685A (zh) 2014-06-18
WO2012103041A3 (en) 2014-05-01
US20120190857A1 (en) 2012-07-26
CA2825475A1 (en) 2012-08-02
HK1199245A1 (en) 2015-06-26
RU2013139300A (ru) 2015-04-10
AR085022A1 (es) 2013-08-07
US20150274669A1 (en) 2015-10-01
JP2014515725A (ja) 2014-07-03
WO2012103041A2 (en) 2012-08-02
KR101537879B1 (ko) 2015-07-17
KR20130121950A (ko) 2013-11-06
EP2668163A2 (en) 2013-12-04
BR102012001636A2 (pt) 2015-07-28
BR112013019025A2 (pt) 2016-07-12
CN104788368A (zh) 2015-07-22
RU2545021C1 (ru) 2015-03-27
PL2668163T3 (pl) 2017-10-31
UA106945C2 (uk) 2014-10-27
TW201309649A (zh) 2013-03-01
SG192093A1 (en) 2013-08-30
TWI592401B (zh) 2017-07-21
CO6731125A2 (es) 2013-08-15
ZA201305577B (en) 2014-09-25
IL227646A0 (en) 2013-09-30
CA2825475C (en) 2017-08-22
EP2668163B1 (en) 2017-05-10
EP2668163A4 (en) 2015-03-11
MX342328B (es) 2016-09-22
IL227646A (en) 2016-10-31
US9067890B2 (en) 2015-06-30
AU2012209277B2 (en) 2015-09-17
CN104788368B (zh) 2017-09-26
JP5739018B2 (ja) 2015-06-24
HK1213875A1 (zh) 2016-07-15
US20140142317A1 (en) 2014-05-22
US9452984B2 (en) 2016-09-27

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