MX2012000889A - Compuesto biciclico y uso del mismo para propositos medicos. - Google Patents
Compuesto biciclico y uso del mismo para propositos medicos.Info
- Publication number
- MX2012000889A MX2012000889A MX2012000889A MX2012000889A MX2012000889A MX 2012000889 A MX2012000889 A MX 2012000889A MX 2012000889 A MX2012000889 A MX 2012000889A MX 2012000889 A MX2012000889 A MX 2012000889A MX 2012000889 A MX2012000889 A MX 2012000889A
- Authority
- MX
- Mexico
- Prior art keywords
- eyes
- medical purposes
- bicyclic compound
- glaucoma
- prodrug
- Prior art date
Links
- -1 Bicyclic compound Chemical class 0.000 title 1
- 208000006069 Corneal Opacity Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000269 corneal opacity Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002740 effect on eyes Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
- Y10S623/905—Eye
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Image Processing (AREA)
Abstract
Se describe un compuesto representado por la fórmula general (I) (donde la definición para cada grupo es como se describe en la descripción) o una sal, solvato o profármaco del mismo, que tiene una potente y duradera actividad hipotensiva ocular y no tiene efectos secundarios adversos en ojos, tal como irritación en ojos (congestión, opacidades corneales, etc.), y nivel incrementado de proteína acuosa, y que por lo tanto es altamente seguro y se puede usar como un excelente agente profiláctico y/o terapéutico para glaucoma o similar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009175246 | 2009-07-28 | ||
| PCT/JP2010/062587 WO2011013651A1 (ja) | 2009-07-28 | 2010-07-27 | 二環式化合物およびその医薬用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012000889A true MX2012000889A (es) | 2012-02-13 |
Family
ID=43529306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000889A MX2012000889A (es) | 2009-07-28 | 2010-07-27 | Compuesto biciclico y uso del mismo para propositos medicos. |
Country Status (20)
| Country | Link |
|---|---|
| US (10) | US8614340B2 (es) |
| EP (2) | EP2460801B1 (es) |
| JP (3) | JP5652397B2 (es) |
| KR (1) | KR101768235B1 (es) |
| CN (1) | CN102498105B (es) |
| AU (1) | AU2010279183B2 (es) |
| BR (1) | BR112012001797B1 (es) |
| CA (1) | CA2767083C (es) |
| DK (2) | DK2653468T3 (es) |
| ES (2) | ES2567328T3 (es) |
| HU (1) | HUE028874T2 (es) |
| IL (1) | IL217342A (es) |
| MX (1) | MX2012000889A (es) |
| NZ (1) | NZ597626A (es) |
| PL (2) | PL2653468T3 (es) |
| PT (1) | PT2460801E (es) |
| RU (1) | RU2540330C2 (es) |
| TW (1) | TWI466877B (es) |
| WO (1) | WO2011013651A1 (es) |
| ZA (1) | ZA201200797B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8614340B2 (en) * | 2009-07-28 | 2013-12-24 | Ono Pharmaceuticals Co., Ltd. | Bicyclic compound and use thereof for medical purposes |
| WO2012102357A1 (ja) * | 2011-01-27 | 2012-08-02 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
| WO2012102355A1 (ja) | 2011-01-27 | 2012-08-02 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
| US9944217B2 (en) | 2013-02-11 | 2018-04-17 | Ferno-Washington, Inc. | Equipment mounting system |
| WO2015129782A1 (ja) * | 2014-02-27 | 2015-09-03 | 小野薬品工業株式会社 | 選択的ｅｐ２アゴニスト活性を有する化合物 |
| US10385045B2 (en) | 2015-07-23 | 2019-08-20 | Ono Pharmaceutical Co., Ltd. | Compound having EP2 agonist activity |
| CA3017388C (en) * | 2016-04-01 | 2024-03-12 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
| EP3480191B1 (en) * | 2016-06-30 | 2021-09-01 | ONO Pharmaceutical Co., Ltd. | Method for producing bicyclic compound |
| WO2019124489A1 (ja) * | 2017-12-21 | 2019-06-27 | 参天製薬株式会社 | セペタプロストとｅｐ２アゴニストとの組み合わせ医薬 |
| ES2972934T3 (es) | 2017-12-21 | 2024-06-17 | Santen Pharmaceutical Co Ltd | Combinación de sepetaprost y ripasudil para su uso en la profilaxis o tratamiento del glaucoma o hipertensión ocular |
| ES2978499T3 (es) * | 2017-12-21 | 2024-09-13 | Ono Pharmaceutical Co | Agente terapéutico para el glaucoma que comprende un agonista fp y timolol |
| CN116159601B (zh) * | 2019-03-15 | 2024-07-23 | 博瑞生物医药（苏州）股份有限公司 | 艾日布林中间体及其制备方法 |
| CA3154867A1 (en) * | 2019-09-19 | 2021-03-25 | Polyactiva Pty Ltd | Biodegradable drug-polymer conjugate |
| US11608319B2 (en) | 2019-12-31 | 2023-03-21 | Industrial Technology Research Institute | Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase |
| WO2021145356A1 (ja) * | 2020-01-15 | 2021-07-22 | 参天製薬株式会社 | 近視の治療、近視の予防および／または近視の進行抑制のための医薬組成物 |
| WO2022034909A1 (ja) | 2020-08-13 | 2022-02-17 | 参天製薬株式会社 | セペタプロストを含有する医薬製剤 |
| CN116947725A (zh) * | 2022-04-14 | 2023-10-27 | 广州楷石医药有限公司 | 曲伏前列素的合成方法 |
| JPWO2023204297A1 (es) | 2022-04-22 | 2023-10-26 | ||
| TW202539693A (zh) * | 2024-01-24 | 2025-10-16 | 日商參天製藥股份有限公司 | 用以使罹患青光眼或高眼壓症之患者於夜間睡眠時之眼壓下降之含有賽佩普斯特(Sepetaprost)之點眼液 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US425417A (en) * | 1890-04-15 | Wall-paper exhibitor | ||
| JPS5411311B2 (es) | 1973-08-11 | 1979-05-14 | ||
| IL51189A (en) | 1976-02-04 | 1985-08-30 | Upjohn Co | Prostaglandin analogs |
| FI71138C (fi) | 1976-12-31 | 1986-11-24 | Erba Farmitalia | Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner |
| CA1184906A (en) | 1977-04-19 | 1985-04-02 | Roy A. Johnson | 9-deoxy-5,9-epoxy-prostaglandins |
| US4490537A (en) * | 1977-04-19 | 1984-12-25 | The Upjohn Company | Enlarged-hetero-ring prostacyclin analogs |
| US4490548A (en) * | 1977-04-19 | 1984-12-25 | The Upjohn Company | Enlarged-hetero-ring prostacyclin analogs |
| US4209615A (en) * | 1977-04-19 | 1980-06-24 | The Upjohn Company | Phenyl-substituted 9-deoxy-6,9α-epoxymethano-PG analogs |
| US4169841A (en) * | 1977-04-19 | 1979-10-02 | The Upjohn Company | Alkenyl-substituted 9-deoxy-6,9-α-epoxymethano-PG analogs |
| JPS5573678A (en) | 1978-11-29 | 1980-06-03 | Ono Pharmaceut Co Ltd | Simultated compound of thio-prostaglandin i1, its preparation and drug composition containing it as active ingredient |
| DE2947526A1 (de) | 1978-11-29 | 1980-06-12 | Ono Pharmaceutical Co | Prostacyclin-analoge |
| JPS6468367A (en) * | 1987-09-08 | 1989-03-14 | Ono Pharmaceutical Co | Novel bicyclic ethers or lactones |
| PT1426361E (pt) | 1999-10-15 | 2008-10-08 | Sucampo Ag | Nova composição contendo um composto bicíclico e um glicérido |
| JP5037780B2 (ja) | 2003-05-23 | 2012-10-03 | 三菱化学株式会社 | 活性エネルギー線硬化性組成物及びハードコートフィルム |
| US7906552B2 (en) | 2004-08-10 | 2011-03-15 | Allergan, Inc. | Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| AU2007261034B2 (en) * | 2006-06-20 | 2012-09-13 | Allergan, Inc. | Therapeutic compounds |
| WO2010067721A1 (ja) | 2008-12-10 | 2010-06-17 | コニカミノルタホールディングス株式会社 | 有機エレクトロルミネッセンス素子の製造方法、有機エレクトロルミネッセンス素子 |
| JP5384959B2 (ja) | 2009-01-28 | 2014-01-08 | セミコンダクター・コンポーネンツ・インダストリーズ・リミテッド・ライアビリティ・カンパニー | 電子回路 |
| US9280875B2 (en) | 2009-03-06 | 2016-03-08 | Zynga Inc. | Virtual playing chips in a multiuser online game network |
| US8614340B2 (en) * | 2009-07-28 | 2013-12-24 | Ono Pharmaceuticals Co., Ltd. | Bicyclic compound and use thereof for medical purposes |
| CN102336754B (zh) | 2010-07-15 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成方法及其中间体化合物 |
| WO2012102355A1 (ja) | 2011-01-27 | 2012-08-02 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
| WO2012102357A1 (ja) | 2011-01-27 | 2012-08-02 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
| US9689114B2 (en) * | 2014-08-07 | 2017-06-27 | Georgia-Pacific Chemicals Llc | Strengthening resins for paper products |
| EP3480191B1 (en) * | 2016-06-30 | 2021-09-01 | ONO Pharmaceutical Co., Ltd. | Method for producing bicyclic compound |
-
2010
- 2010-07-27 US US13/384,383 patent/US8614340B2/en active Active
- 2010-07-27 CA CA2767083A patent/CA2767083C/en active Active
- 2010-07-27 MX MX2012000889A patent/MX2012000889A/es active IP Right Grant
- 2010-07-27 TW TW99124651A patent/TWI466877B/zh active
- 2010-07-27 AU AU2010279183A patent/AU2010279183B2/en active Active
- 2010-07-27 WO PCT/JP2010/062587 patent/WO2011013651A1/ja not_active Ceased
- 2010-07-27 HU HUE13003505A patent/HUE028874T2/en unknown
- 2010-07-27 ES ES13003505.8T patent/ES2567328T3/es active Active
- 2010-07-27 CN CN201080041706.2A patent/CN102498105B/zh active Active
- 2010-07-27 JP JP2011524785A patent/JP5652397B2/ja active Active
- 2010-07-27 EP EP10804397.7A patent/EP2460801B1/en active Active
- 2010-07-27 KR KR1020127002415A patent/KR101768235B1/ko active Active
- 2010-07-27 PL PL13003505T patent/PL2653468T3/pl unknown
- 2010-07-27 PL PL10804397T patent/PL2460801T3/pl unknown
- 2010-07-27 PT PT10804397T patent/PT2460801E/pt unknown
- 2010-07-27 RU RU2012107109/04A patent/RU2540330C2/ru active
- 2010-07-27 BR BR112012001797A patent/BR112012001797B1/pt active IP Right Grant
- 2010-07-27 DK DK13003505.8T patent/DK2653468T3/en active
- 2010-07-27 NZ NZ597626A patent/NZ597626A/xx unknown
- 2010-07-27 EP EP13003505.8A patent/EP2653468B1/en active Active
- 2010-07-27 DK DK10804397.7T patent/DK2460801T3/da active
- 2010-07-27 ES ES10804397.7T patent/ES2500067T3/es active Active
-
2012
- 2012-01-03 IL IL217342A patent/IL217342A/en active IP Right Grant
- 2012-02-01 ZA ZA2012/00797A patent/ZA201200797B/en unknown
-
2013
- 2013-11-15 US US14/081,286 patent/US8962868B2/en active Active
-
2014
- 2014-11-17 JP JP2014233001A patent/JP5935857B2/ja active Active
- 2014-12-31 US US14/587,829 patent/US9388157B2/en active Active
-
2016
- 2016-05-12 JP JP2016096312A patent/JP6149975B2/ja active Active
- 2016-06-13 US US15/180,125 patent/US9889114B2/en active Active
-
2017
- 2017-12-22 US US15/852,493 patent/US10201520B2/en active Active
-
2018
- 2018-12-21 US US16/229,446 patent/US20190111019A1/en not_active Abandoned
-
2019
- 2019-11-27 US US16/698,432 patent/US10940134B2/en active Active
-
2021
- 2021-01-14 US US17/149,327 patent/US11617733B2/en active Active
-
2023
- 2023-02-15 US US18/169,716 patent/US12201603B2/en active Active
-
2024
- 2024-12-11 US US18/977,109 patent/US20250099419A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ597626A (en) | Bicyclic compound and use thereof for medical purposes | |
| MX2020003055A (es) | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. | |
| AU2012243329A8 (en) | 5-substituted iminothiazines and their mono-and dioxides as BACE inhibitors,compositions,and their use | |
| MX2017012393A (es) | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. | |
| MX2014002113A (es) | Iminotiazinas sustituidas en 2-espiro y sus mono y bioxidos como inhibidores de enzima de disociacion de proteina precursora amiloide del sitio beta, composiciones, y su uso. | |
| NZ627827A (en) | Antiviral combinations involving (3s, 11ar)-n-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide | |
| MY161095A (en) | Indole compound and pharmaceutical use thereof | |
| HK1198631A1 (en) | Prevention and treatment of ocular conditions | |
| CA2897273C (en) | Benzylamine derivatives | |
| UA95105C2 (ru) | Применение производного лактамида для снижения токсичности в препарате, который может соприкасаться с кожей или глазами человека или животного, производные лактамида и способы их получения | |
| MX360634B (es) | Inhibidores de 3-haloalilamina sustituidos de ssao y uso de los mismos. | |
| WO2013106385A3 (en) | System and methods for determining tissue elasticity | |
| BR112014025711A2 (pt) | composto, medicamento, e, uso de um composto | |
| WO2018033792A3 (en) | Ophthalmic pharmaceutical compositions and uses relating thereto | |
| WO2008146721A1 (ja) | 加齢黄斑変性の予防又は治療剤 | |
| PH12016501651B1 (en) | Triazine compound and use thereof for medical purposes | |
| HK1211290A1 (en) | Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases | |
| WO2011116020A3 (en) | Ophthalmic formulations of cetirizine and methods of use | |
| HK1208441A1 (en) | Fluorinated bridged spiro[2.4]heptane derivatives as alx receptor agonists | |
| MX2014003194A (es) | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. | |
| PH12015500012B1 (en) | Benzodioxole derivative and preparation method and use thereof | |
| PH12013500416A1 (en) | Adenosine a1 agonists for the treatment of glaucoma and ocular hypertension | |
| MX2009007040A (es) | Derivados de mononitrato de isosorbida para el tratamiento de hipertension ocular. | |
| EP4494705A3 (en) | Non-peptide oxytocin receptor agonists | |
| MX379373B (es) | Derivado de sulfonamida heterocíclico y medicina que contiene el mismo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |