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MX2008008470A - Novel pyrrole derivatives with histone deacetylase inhibitor activity. - Google Patents

Novel pyrrole derivatives with histone deacetylase inhibitor activity.

Info

Publication number
MX2008008470A
MX2008008470A MX2008008470A MX2008008470A MX2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A
Authority
MX
Mexico
Prior art keywords
inhibitor activity
histone deacetylase
pyrrole derivatives
deacetylase inhibitor
novel pyrrole
Prior art date
Application number
MX2008008470A
Other languages
Spanish (es)
Inventor
Fernando Pedro Cossio Mora
Aizpea Zubia Olascoaga
Dorleta Otaegui Ansa
Manuel Esteller Badosa
Original Assignee
Univ Pais Vasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pais Vasco filed Critical Univ Pais Vasco
Publication of MX2008008470A publication Critical patent/MX2008008470A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel pyrrole derivatives having formula (I), to methods for obtaining same and to the use thereof as drugs for the treatment of cancer in pharmaceutical compositions owing to the inhibitor activity of said derivatives in relation to certain histone deacetylases.
MX2008008470A 2005-12-27 2005-12-27 Novel pyrrole derivatives with histone deacetylase inhibitor activity. MX2008008470A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2005/000708 WO2007074176A1 (en) 2005-12-27 2005-12-27 Novel pyrrole derivatives with histone deacetylase inhibitor activity

Publications (1)

Publication Number Publication Date
MX2008008470A true MX2008008470A (en) 2008-09-26

Family

ID=38217700

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008008470A MX2008008470A (en) 2005-12-27 2005-12-27 Novel pyrrole derivatives with histone deacetylase inhibitor activity.

Country Status (17)

Country Link
US (1) US7638550B2 (en)
EP (1) EP1975158B9 (en)
JP (1) JP4975758B2 (en)
CN (1) CN101351444B (en)
AT (1) ATE516268T1 (en)
AU (1) AU2005339535B2 (en)
BR (1) BRPI0520806A2 (en)
CA (1) CA2635392C (en)
CY (1) CY1111899T1 (en)
DK (1) DK1975158T3 (en)
ES (1) ES2369705T3 (en)
MX (1) MX2008008470A (en)
PL (1) PL1975158T3 (en)
PT (1) PT1975158E (en)
RU (1) RU2416600C2 (en)
SI (1) SI1975158T1 (en)
WO (1) WO2007074176A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090298905A1 (en) * 2005-04-15 2009-12-03 Fernando Pedro Cossio Nitrogenatd trans-stilbene analogs, method for the obtention and medical applications thereof
EP2305643A1 (en) * 2009-10-02 2011-04-06 Ikerchem, S.L. New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
EP2508510A1 (en) * 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
CN103373969B (en) * 2012-04-27 2015-09-16 中国科学院上海有机化学研究所 Phenyl azoles ring substituted amide compounds and its production and use
PT3297992T (en) 2015-05-22 2020-03-17 Chong Kun Dang Pharmaceutical Corp Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same
CN106565583A (en) * 2016-11-15 2017-04-19 淮阴师范学院 Preparation method of polysubstitued pyrrole derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935990A (en) * 1996-12-10 1999-08-10 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
JP4191825B2 (en) * 1998-09-10 2008-12-03 あすか製薬株式会社 5-aminoisoxazole derivatives
YU22402A (en) * 1999-09-08 2006-01-16 Sloan-Kettering Institute For Cancer Research Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
IL150965A0 (en) * 2000-01-31 2003-02-12 Ishihara Sangyo Kaisha Therapeutic or preventive agent for digestive system diseases containing a diaminotrifluoromethylpyridine derivative
ATE430567T1 (en) * 2000-09-29 2009-05-15 Topotarget Uk Ltd CARBAMINIC ACID DERIVATIVES CONTAINING AN AMIDE GROUP FOR THE TREATMENT OF MALARIA
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
JP4716996B2 (en) * 2003-05-26 2011-07-06 武田薬品工業株式会社 Sulfopyrrole
JP2007513144A (en) 2003-12-05 2007-05-24 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー N-alkylpyrroles as HMG-CoA reductase inhibitors
EP1725528B1 (en) * 2004-03-11 2013-05-29 4Sc Ag Sulphonylpyrroles as hdac inhibitors

Also Published As

Publication number Publication date
AU2005339535A1 (en) 2007-07-05
RU2416600C2 (en) 2011-04-20
AU2005339535B2 (en) 2012-02-23
WO2007074176A1 (en) 2007-07-05
CN101351444B (en) 2011-07-13
JP2009521519A (en) 2009-06-04
EP1975158A1 (en) 2008-10-01
CA2635392A1 (en) 2007-07-05
EP1975158B1 (en) 2011-07-13
PL1975158T3 (en) 2011-12-30
US20080262073A1 (en) 2008-10-23
ES2369705T3 (en) 2011-12-05
DK1975158T3 (en) 2011-10-24
BRPI0520806A2 (en) 2009-06-09
CY1111899T1 (en) 2015-11-04
EP1975158B9 (en) 2012-02-29
ATE516268T1 (en) 2011-07-15
CA2635392C (en) 2013-07-23
RU2008130876A (en) 2010-02-10
JP4975758B2 (en) 2012-07-11
SI1975158T1 (en) 2011-10-28
CN101351444A (en) 2009-01-21
US7638550B2 (en) 2009-12-29
EP1975158A4 (en) 2009-11-11
HK1125926A1 (en) 2009-08-21
PT1975158E (en) 2011-09-23

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