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MX2007012659A - Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90. - Google Patents

Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90.

Info

Publication number
MX2007012659A
MX2007012659A MX2007012659A MX2007012659A MX2007012659A MX 2007012659 A MX2007012659 A MX 2007012659A MX 2007012659 A MX2007012659 A MX 2007012659A MX 2007012659 A MX2007012659 A MX 2007012659A MX 2007012659 A MX2007012659 A MX 2007012659A
Authority
MX
Mexico
Prior art keywords
sup
optionally substituted
hydroxy
hydrogen
ring members
Prior art date
Application number
MX2007012659A
Other languages
English (en)
Inventor
Michael Alistair O'brien
Maria Grazia Carr
Eva Figueroa Navarro
Alison Jo-Anne Woolford
Andrew James Woodhead
Robert Downham
Theresa Rachel Phillips
Gianni Chessari
Miles Stuart Congreve
Martyn Frederickson
Christopher Murray
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36808863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007012659(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0507474A external-priority patent/GB0507474D0/en
Priority claimed from GB0604111A external-priority patent/GB0604111D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MX2007012659A publication Critical patent/MX2007012659A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

La invencion proporciona compuestos de la Formula (I) (ver Formula (I)): o sales, tautomeros, solvatos, y N-oxidos de los mismos; en donde R1 es hidroxilo o hidrogeno; R2 es hidroxilo, metoxilo o hidrogeno; en el entendido de que cuando menos uno de R1 y R2 es hidroxilo; R3 se selecciona a partir de hidrogeno; halogeno; ciano; hidrocarbilo de 1 a 5 atomos de carbono opcionalmente sustituido, e hidrocarbiloxilo de 1 a 5 atomos de carbono opcionalmente sustituido; R4 se selecciona a partir de hidrogeno; un grupo -(O)n-R7 en donde n es 0 o 1, y R7 es un grupo hidrocarbilo de 1 a 5 atomos de carbono aciclico opcionalmente sustituido, o un grupo carbociclico o heterociclico monociclico que tiene de 3 a 7 miembros del anillo; halogeno; ciano; hidroxilo; amino; y mono- o di- hidrocarbilo de 1 a 5 atomos de carbono-amino opcionalmente sustituido; o R3 y R4 forman juntos un anillo carbociclico o heterociclico monociclico de 5 a 7 miembros del anillo; y NR5R6 forma un grupo heterociclico biciclico opcionalmente sustituido que tiene de 8 a 12 miembros del anillo, de los cuales hasta 5 miembros del anillo son heteroatomos seleccionados a partir de oxigeno, nitrogeno y azufre. Los compuestos tienen actividad como inhibidores de Hsp90.
MX2007012659A 2005-04-13 2006-04-13 Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90. MX2007012659A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US67089705P 2005-04-13 2005-04-13
GB0507474A GB0507474D0 (en) 2005-04-13 2005-04-13 Pharmaceutical compounds
US77798906P 2006-03-01 2006-03-01
GB0604111A GB0604111D0 (en) 2006-03-01 2006-03-01 Pharmaceutical compounds
PCT/GB2006/001382 WO2006109085A1 (en) 2005-04-13 2006-04-13 Hydroxybenzamide derivatives and their use as inhibitors of hsp90

Publications (1)

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MX2007012659A true MX2007012659A (es) 2008-01-11

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MX2007012659A MX2007012659A (es) 2005-04-13 2006-04-13 Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90.

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US (7) US20080306054A1 (es)
EP (3) EP2332909B1 (es)
JP (2) JP5154406B2 (es)
KR (1) KR101411167B1 (es)
CN (1) CN101193862B (es)
AU (1) AU2006235735C1 (es)
CA (1) CA2604042C (es)
DK (2) DK2332909T3 (es)
ES (2) ES2402469T3 (es)
ME (2) ME02051B (es)
MX (1) MX2007012659A (es)
NO (1) NO341631B1 (es)
NZ (1) NZ562199A (es)
PL (2) PL2332909T3 (es)
PT (2) PT2332909E (es)
RS (2) RS52715B (es)
RU (1) RU2458919C2 (es)
SI (2) SI2332909T1 (es)
TW (1) TWI378090B (es)
WO (2) WO2006109085A1 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0607235A2 (pt) 2005-02-24 2009-08-25 Amgen Inc mutações do receptor do fator de crescimento epidérmico
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