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MA42244B1 - Dérivés de 3-tétrazolyl-benzène-1,2-disulfonamide en tant qu'inhibiteurs de métallo-bêta-lactamase - Google Patents

Dérivés de 3-tétrazolyl-benzène-1,2-disulfonamide en tant qu'inhibiteurs de métallo-bêta-lactamase

Info

Publication number
MA42244B1
MA42244B1 MA42244A MA42244A MA42244B1 MA 42244 B1 MA42244 B1 MA 42244B1 MA 42244 A MA42244 A MA 42244A MA 42244 A MA42244 A MA 42244A MA 42244 B1 MA42244 B1 MA 42244B1
Authority
MA
Morocco
Prior art keywords
beta
metallo
lactamase inhibitor
pharmaceutically acceptable
tetrazolyl
Prior art date
Application number
MA42244A
Other languages
English (en)
Other versions
MA42244A (fr
Inventor
Zhibo Zhang
Alexander Pasternak
Jinlong Jiang
Xin Gu
Frank Bennett
Shuzhi Dong
Jack Scott
Haiqun Tang
Zhiqiang Zhao
Yuhua Huang
Dexi Yang
Katherine Young
Li Xiao
Jianmin Fu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA42244A publication Critical patent/MA42244A/fr
Publication of MA42244B1 publication Critical patent/MA42244B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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Abstract

La présente invention concerne des composés inhibiteurs de métallo-bêta-lactamase représentés par la formule i, et leurs sels pharmaceutiquement acceptables. Dans ladite formule, z, ra, x1, x 2 et r1 sont tels que définis ici. La présente invention concerne également des compositions qui comprennent un composé inhibiteur de métallo-bêta-lactamase ou son sel pharmaceutiquement acceptable, et un support pharmaceutiquement acceptable, éventuellement associé à un antibiotique bêta-lactame et/ou un inhibiteur de bêta-lactamase. L'invention concerne également des procédés permettant de traiter une infection bactérienne qui consistent à administrer à un patient une quantité thérapeutiquement efficace d'un composé de l'invention, en l'associant à une quantité thérapeutiquement efficace d'un ou de plusieurs antibiotiques bêta-lactame et éventuellement en l'associant à un ou plusieurs composés inhibiteurs de bêta-lactamase. Les composés de l'invention sont utiles dans les procédés de l'invention pour surmonter la résistance aux antibiotiques.
MA42244A 2015-06-26 2016-06-24 Dérivés de 3-tétrazolyl-benzène-1,2-disulfonamide en tant qu'inhibiteurs de métallo-bêta-lactamase MA42244B1 (fr)

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PCT/CN2015/082514 WO2016206101A1 (fr) 2015-06-26 2015-06-26 Inhibiteurs de métallo-bêta-lactamases
PCT/US2016/039156 WO2016210215A1 (fr) 2015-06-26 2016-06-24 Dérivés de 3-tétrazolyl-benzène-1,2-disulfonamide en tant qu'inhibiteurs de métallo-bêta-lactamase

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TW201713633A (en) 2017-04-16
MA42244A (fr) 2018-05-02
MX385838B (es) 2025-03-18
MX2017016672A (es) 2018-07-06
IL256265B (en) 2021-08-31
EA201890150A1 (ru) 2018-05-31
GEP20207169B (en) 2020-10-12
CO2017013360A2 (es) 2018-03-20
US20190144432A1 (en) 2019-05-16
EP3313828A4 (fr) 2019-01-09
WO2016210215A1 (fr) 2016-12-29
RS61696B1 (sr) 2021-05-31
BR112017027719B1 (pt) 2024-02-06
ES2865284T3 (es) 2021-10-15
WO2016210234A1 (fr) 2016-12-29
US10221163B2 (en) 2019-03-05
DK3313832T3 (da) 2021-04-19
AU2016281710B2 (en) 2018-10-11
US20180244656A1 (en) 2018-08-30
EA032698B1 (ru) 2019-07-31
GEAP202014683A (en) 2020-05-11
EP3313828B1 (fr) 2023-07-12
JO3588B1 (ar) 2020-07-05
WO2016206101A1 (fr) 2016-12-29
HRP20210481T1 (hr) 2021-08-20
JP6409141B2 (ja) 2018-10-17
CA2990234C (fr) 2020-07-21
PH12017502418A1 (en) 2018-07-02
PL3313832T3 (pl) 2021-07-05
CR20170605A (es) 2018-05-15
ECSP18005828A (es) 2018-04-30
US10544130B2 (en) 2020-01-28
CL2017003325A1 (es) 2018-05-11
JP2018522864A (ja) 2018-08-16
TWI715595B (zh) 2021-01-11

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