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Macdonald et al., 2000 - Google Patents

PPARα-dependent alteration of GRP94 expression in mouse hepatocytes

Macdonald et al., 2000

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Document ID
267143492890441383
Author
Macdonald N
Barrow K
Tonge R
Davison M
Roberts R
Chevalier S
Publication year
Publication venue
Biochemical and biophysical research communications

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Snippet

The adverse effects of the peroxisome proliferators (PPs), a class of rodent nongenotoxic hepatocarcinogens, include suppression of apoptosis, induction of hepatocyte proliferation, and liver enlargement which eventually leads to tumours. The response to PPs is mediated …
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