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Somaida et al., 2025 - Google Patents

Improved oral bioavailability of paclitaxel through folate-engineered zein nanoparticles: evaluation in intestinal organoid and in vivo models

Somaida et al., 2025

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Document ID
9459293763492062362
Author
Somaida A
Abdelsalam A
Khedr S
Mohamed A
Tariq I
Almohsen N
Ashraf O
Osman S
Al-Sawahli M
Engelhardt K
Bakowsky U
Publication year
Publication venue
International Journal of Biological Macromolecules

External Links

Snippet

Oral administration remains the most accessible route for drug delivery. Paclitaxel is a natural lipophilic agent with significant antineoplastic efficacy against various malignancies. However, its clinical application is limited by low solubility, systemic toxicity, and poor …
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Classifications

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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
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