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Bilateral Symmetrical Oral Lichenoid Reaction in an Epileptic Patient due to Karbalex Retard (Carbamazepine) 600 mg: An Unusual Case Report

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Abstract

Background

Karbalex, with its carbamazepine as an active ingredient, is used to treat various types of epilepsy. Despite being uncommon, the present case highlights how crucial it is to take oral lichenoid reactions into account, particularly in patients who use Karbalex, when making a differential diagnosis of oral mucosal lesions.

Case Presentation

The rare case of a 20-year-old man with a history of generalised epilepsy is described in this article. He sought consultation because of pain from mouth sores and a burning sensation when consuming cold, hot, and spicy meals, among other symptoms. For the previous five months, the patient was taking Karbalex Retard 600 mg. The diagnosis of bilateral symmetrical oral lichenoid reaction caused by Karbalex Retard 600 mg was confirmed by clinical and histological analysis. The patient was treated by stopping Karbalex Retard 600 mg and beginning with Tegretol 400 mg. The patient noticed that his mouth was starting to recover 2 months after stopping Karbalex Retard. After an additional month, all the symptoms of oral lichenoid reactions disappeared totally, which confirmed the diagnosis.

Conclusion

This is an unusual case of a bilateral symmetrical oral lichenoid reaction caused by Karbalex Retard (Carbamazepine) 600 in an epileptic patient. Despite being uncommon, this case report is worth highlighting because, by removing the differential diagnosis and offering an early diagnosis, it may prevent vulnerable individuals from displaying severe symptoms.

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Data Availability

No datasets were generated or analysed during the current study.

Code Availability

Not applicable.

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Author information

Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Uşak University, 64200, Uşak, Turkey

    Ahmed Badri Abed

  2. Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Tınaztepe University, İzmir, Turkey

    Şehrazat Erensoy

  3. Uşak Health Training School, Uşak University, 64200, Uşak, Turkey

    Safiye Elif Korcan

  4. Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Uşak University, Uşak, Turkey

    İsmail Ongun

  5. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Uşak University, Uşak, Turkey

    Muhammed Fatih Çiçek

Authors
  1. Ahmed Badri Abed
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  2. Şehrazat Erensoy
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  3. Safiye Elif Korcan
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  4. İsmail Ongun
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  5. Muhammed Fatih Çiçek
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Contributions

ABA.: Conceptualization, Design, Data collection, Analysis, Literature research, Original Draft, Writing - Review & Editing, ŞE: Conceptualization, Design, Project administration, Supervision, Methodology, SEK: Conceptualization, Design, Project administration, Supervision, Methodology, İO: Writing - Review & Editing, Visualization, Investigation, MFÇ: Visualization, Investigation, Data Curation.

Corresponding author

Correspondence to Ahmed Badri Abed.

Ethics declarations

Ethics Approval and Consent to Participate

This study was performed in line with the principles of the Declaration of Helsinki. All the clinical procedures were legally authorized and approved by the Oral and Dental Health Application and Research Center Directorate/Uşak University. Informed consent was obtained from the patient in this study.

Consent for Publication

Written Consent for publication was obtained from the patient in this study.

Competing interests

The authors declare no competing interests.

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Abed, A.B., Erensoy, Ş., Korcan, S.E. et al. Bilateral Symmetrical Oral Lichenoid Reaction in an Epileptic Patient due to Karbalex Retard (Carbamazepine) 600 mg: An Unusual Case Report. SN Compr. Clin. Med. 7, 316 (2025). https://doi.org/10.1007/s42399-025-02077-x

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  • DOI: https://doi.org/10.1007/s42399-025-02077-x

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