diff --git a/app/services/ci/job_artifacts/create_service.rb b/app/services/ci/job_artifacts/create_service.rb
index ae131462e0906dd3e37d4813b130c055aed4e096..509787a31cd6588abc5a4544044e205a07ee1c39 100644
--- a/app/services/ci/job_artifacts/create_service.rb
+++ b/app/services/ci/job_artifacts/create_service.rb
@@ -127,7 +127,9 @@ def build_metadata_artifact(job_artifact, metadata_file)
       end
 
       def expire_in(params)
-        params['expire_in'] || Gitlab::CurrentSettings.current_application_settings.default_artifacts_expire_in
+        params['expire_in'] ||
+          job.options.dig(:artifacts, :expire_in) ||
+          Gitlab::CurrentSettings.current_application_settings.default_artifacts_expire_in
       end
 
       def accessibility(params)
diff --git a/doc/ci/yaml/_index.md b/doc/ci/yaml/_index.md
index 59e73b3a310df09264cea8a4887716c24d4de299..1c32de35f845ded688ace706d76edb8e4b88d6ed 100644
--- a/doc/ci/yaml/_index.md
+++ b/doc/ci/yaml/_index.md
@@ -121,7 +121,7 @@ is not used.
 **Supported values**: These keywords can have custom defaults:
 
 - [`after_script`](#after_script)
-- [`artifacts`](#artifacts), though due to [issue 404563](https://gitlab.com/gitlab-org/gitlab/-/issues/404563), the nested keyword `artifacts:expire_in` has no effect.
+- [`artifacts`](#artifacts)
 - [`before_script`](#before_script)
 - [`cache`](#cache)
 - [`hooks`](#hooks)
diff --git a/spec/services/ci/job_artifacts/create_service_spec.rb b/spec/services/ci/job_artifacts/create_service_spec.rb
index 3912835ffd3912cd8cfab4d1d22bd909c7c79fcf..70b1f5a4779cd173435920e3a6adb33b928e63c0 100644
--- a/spec/services/ci/job_artifacts/create_service_spec.rb
+++ b/spec/services/ci/job_artifacts/create_service_spec.rb
@@ -287,6 +287,46 @@
             expect(metadata_artifact.expire_at).to eq(expected_expire_at)
           end
         end
+
+        context 'when expire_in is set in job options' do
+          let_it_be(:job) do
+            create(:ci_build, project: project,
+              options: { artifacts: { expire_in: '3 hours', paths: ['path1'] } })
+          end
+
+          it 'sets expiration date according to the job options' do
+            expected_expire_at = 3.hours.from_now
+
+            expect(execute).to match(a_hash_including(status: :success, artifact: anything))
+            archive_artifact, metadata_artifact = job.job_artifacts.last(2)
+
+            expect(job.artifacts_expire_at).to be_within(1.minute).of(expected_expire_at)
+            expect(archive_artifact.expire_at).to be_within(1.minute).of(expected_expire_at)
+            expect(metadata_artifact.expire_at).to be_within(1.minute).of(expected_expire_at)
+          end
+        end
+
+        context 'when `expire_in` is set in both params and job options' do
+          let(:job) do
+            create(:ci_build, project: project,
+              options: { artifacts: { expire_in: '3 hours', paths: ['path1'] } })
+          end
+
+          before do
+            params.merge!('expire_in' => '1 day')
+          end
+
+          it 'prioritizes params `expire_in` over job options `expire_in`' do
+            expected_expire_at = 1.day.from_now
+
+            expect(execute).to match(a_hash_including(status: :success, artifact: anything))
+            archive_artifact, metadata_artifact = job.job_artifacts.last(2)
+
+            expect(job.artifacts_expire_at).to be_within(1.minute).of(expected_expire_at)
+            expect(archive_artifact.expire_at).to be_within(1.minute).of(expected_expire_at)
+            expect(metadata_artifact.expire_at).to be_within(1.minute).of(expected_expire_at)
+          end
+        end
       end
     end