Problems with simulations of stiff models

1. Allow to specify options for IQMPsimulate (reltol, abstol, maxnumsteps), otherwise stiff models simulation may fail instead of just taking longer time.

2. Do not stop on IQMPsimulate errors, but instead:

   • try to increase maxnumsteps (e.g. twice by ten)
   • allow to specify a fixed cost for non-computable simulations, e.g. as an offset wrt viability threshold given by its multiplier (infvtm by default 0, i.e. not specified).

Sample from Claude attached; Km* < 1 values are too stiff for current 1e-12 tolerance and 1e6 max number of steps between two output points, but works with default values.

topo_MAPK.m paramSpecs.txt MAPK_model5.txtbc expData_design.xls exp-input.exp exp-alpha.exp