MTHFR is a gene in the methylation pathway that is responsible for converting folate into methylfolate which is the methylated active form of folate which then goes on to support the production of SAMe. Methylation is the addition of a methyl group to a molecule which activates the receiving molecule. The “activated” molecule can then go on to support other functions in the body. SAMe is one of your body’s main methyl donors that is required as a co-factor for 200 plus other genes