Pathogenesis articles from across Nature Portfolio

Vaccine-induced immune thrombotic thrombocytopenia is a rare complication of adenoviral vector-based COVID-19 vaccines. New data show that vaccine-induced immune thrombotic thrombocytopenia arises from molecular mimicry between platelet factor 4 and adenoviral core protein VII after the acquisition of the K31E mutation in the IgG light chain in individuals who carry the IGLV3-21*02 or IGLV3-21*03 alleles.

This study reveals how Toxoplasma gondii exits host cells to spread infection. Researchers found that a key protein, MIC11, works with parasite perforin to disrupt membranes—a mechanism conserved even in the feline stages of infection.

Vaccine-induced immune thrombotic thrombocytopenia is a rare complication of adenoviral vector-based COVID-19 vaccines. New data show that vaccine-induced immune thrombotic thrombocytopenia arises from molecular mimicry between platelet factor 4 and adenoviral core protein VII after the acquisition of the K31E mutation in the IgG light chain in individuals who carry the IGLV3-21*02 or IGLV3-21*03 alleles.

Spatial transcriptomics analyses reveal that fibrogenic fibroblasts dictate treatment outcomes in rheumatoid arthritis.

Comparing dermatomyositis with cutaneous lupus erythematosus, single-cell analysis identifies monocyte-mediated endothelial injury as a dermatomyositis-specific feature and highlights JAK1 inhibition as a potential therapeutic approach.