The behavior of liquids approaching the glass state is significantly influenced by their configurational entropy, which is crucial for understanding their dynamics and thermodynamics. This study successfully extends the potential energy landscape formalism to quantum liquids, demonstrating that configurational entropy can be defined similarly to classical liquids and that the Adam-Gibbs relation holds.

Making useful nitrogen compounds directly from nitrogen gas and simple aromatic molecules has been a major chemical challenge. A sodium hydride magnesium oxide surface enables direct carbon–nitrogen bond formation and selectively produces aniline.

Despite the technological advancements in optical metasurfaces, the integration of multiple functions with a single device is challenging. Here, authors propose a multifunctional metasurface based on engineered structural disorder, demonstrating a broadband metalens with scalable aperture and metasurface-based detection of optical topological textures.

Ortho-disubstituted benzene bioisosteres such as 4,5-disubstituted 2- oxabicyclo[2.1.1]hexanes are attractive scaffolds for improving drug-like properties but remain challenging to access enantioselectively. Here, the authors report a transition-metal-free enantioselective intramolecular [2 + 2] photocycloaddition using cooperative energy transfer and chiral Brønsted acid catalysis.

Molecular aggregates with photophysical behaviour have triplet excitons, but these are not well studied. Here, the authors report the study of triplet exciton behaviour in aggregates of various sizes, and the effect of this on photophysical behaviour.

In this study, authors investigate what happens to magma before a volcanic eruption. They find that crystals react to magma flow before it reaches the surface, preserving a mechanical fingerprint of the forces driving eruptions.

Less than 15% of people in 862 European cities live in full compliance with the 3-30-300 greening rule. Wealthier areas show higher adherence, highlighting urgent needs for equitable urban planning to improve access to green spaces.

A ZnO/CuO catalyst featuring dual-site cooperative framework for polymerization-based wastewater treatment. Zn sites preferentially adsorb/activate organics, whereas Cu sites predominantly activate the oxidant, showcasing atomic-scale design to reactor-scale implementation.

Adsorption of trace transition-metal cations endows common Ca/Mg-carbonates and phyllosilicates with catalytic activity for electrochemical CO2 reduction under planetary conditions, potentially promoting prebiotic chemistry and the origin of life.

The study suggests that long-period seismic bursts are triggered by ocean swell through the activation of cracks and fluid movement in the crust, linking wave activity in the Gulf of Guinea to episodic seismic energy release.

A mode of action guided metagenomic natural product discovery platform, resistance-CONKAT-seq, uncovers the ClpP-targeting calprotamides and reveals convergent evolution of a shared chemical motif to modulate the ClpP protease.

Break-induced replication (BIR) is mediated by DNA polymerase d (Pol d). Here, the authors identify a phospho-activated RPA-binding module in Pol d which promotes BIR efficiency, providing a paradigm for the dynamic regulation of DNA transactions involving single-stranded intermediates bound by RPA.

Rodents are frequently used as models of the human immune system, but not all immune functions are shared between the two evolutionary families. Here the authors provide evidence that the immune system of the tree shrew (Tupaia belangeri) is closer to humans than that of rodents and the single cell immune atlas they assemble support the wider employment of the tree shrew as immunological model.

Somatic variant calling in cancer normally requires matched normal samples, but the latter are often unavailable. Here, the authors develop VarNet-T, a weakly supervised deep learning framework to identify somatic variants in tumours without matched normal controls, demonstrating higher accuracy than other existing methods.

Skeletal muscle fiber type is key to metabolic health. Zhou et al. reveal that the protein BRD4 dictates muscle fiber identity, blocking it promotes energy-burning slow fibers and prevents obesity in mice, offering a new target for metabolic disease.

Inflammatory skin diseases are characterized by immune dysregulation often underpinned by metabolic dysregulation. Here the authors show that in human psoriasis and mouse skin inflammation models, adenosine-mediated crosstalk between fibroblasts and keratinocytes drive mitochondrial dysfunction and pro-inflammatory mediator release in keratinocytes, leading to epidermal inflammation.

Rat hepatitis E virus is an emerging zoonotic pathogen increasingly linked to human acute and chronic hepatitis. This Review examines its ecology, molecular diversity and clinical relevance, and highlights priorities for improving diagnosis, surveillance and prevention.

Desmoplastic small round cell tumor (DSRCT), a very rare and understudied sarcoma, presents serious challenges for both diagnosis and treatment. Here, the authors employ multi-omics profiling on 30 refractory DSRCT patients to improve the diagnosis and identify potentially actionable targets for individualized DSRCT treatment.

BRCA2 mutations are well known to increase cancer risk, however, the significance of many variants remains unknown. Here, the authors combine data from two saturation genome editing studies to classify a total of 5926 variants as pathogenic or benign.

The authors show brain structural-functional gradient coupling reorganizes during development and predicts cognitive, behavioral, and mental health traits. This heritable neurobiological feature reflects cell-type-specific molecular architecture.

Less than 15% of people in 862 European cities live in full compliance with the 3-30-300 greening rule. Wealthier areas show higher adherence, highlighting urgent needs for equitable urban planning to improve access to green spaces.

House of Piast was one of the royal dynasties that shaped the political structure of medieval Europe in the 10^th century CE. Here, the authors use ancient DNA analysis to build the genetic genealogy tree of this royal family.

Here, the authors leverage stable isotope and peptide analyses to show that some 18th century Māori individuals ate largely plant-based diets. This work aligns with Māori oral history and archaeological evidence, which points to sweet potato and taro cultivation as important for population growth and cultural change at the time.

Tropical thunderstorms cause rapid fluctuations in photovoltaic generation that stress electricity grids. Decentralized electric vehicle charging balances these fluctuations and enables large-scale solar energy deployment in tropical cities.

Lethal heatwaves are traditionally identified using wet-bulb temperature thresholds, which fail to capture vulnerability and adaptability. Here, a model using thermo-temporal trends and public health predicts lethal heat with more than 10x accuracy.