Chan Zuckerberg Biohub Network

🚨 Out today in Science Magazine: comprehensive study combining a new imaging technique with single-cell sequencing reveals a new understanding of ovaries in mice and humans and how they age. Led by Diana Laird, a San Francisco Biohub Investigator and University of California, San Francisco professor of Obstetrics, Gynecology & Reproductive Sciences, working with the #CZBiohubSF Genomics Platform, the study could be key to developing strategies for extended fertility and healthier aging. “By combining the Laird lab’s cutting-edge imaging with the Biohub’s expertise in two kinds of single-cell sequencing, we were able to understand the ovary in unprecedented detail,” said Norma Neff, director of Biohub’s Genomics Platform. “This technology-driven approach let us uncover new cell types, providing a foundation for future discoveries in reproductive health.”   Learn more ⤵️ https://lnkd.in/gKSD6y7T Shown below: An age-dependent decline in the number of eggs (green) and the subset of growing eggs (magenta) quantified in the entire ovary, shown in a mouse at 2 months (left) and 12 months of age (right). #science #fertility #aging #imaging #SingleCellSequencing

⭐ What a day! The Chicago Biohub’s Annual Confab took place on September 29 at the University of Chicago. It was a day dedicated to advancing science through collaboration, innovation, and community. The program featured a keynote by Kelvin Droegemeier, Ph.D., University of Illinois Urbana-Champaign, on shaping a new approach to research and innovation through partnerships designed to drive scientific breakthroughs and deliver impact. We also heard lightning talks from Investigators, faculty, and trainees from #CZBiohubCHI’s three partner universities -- Northwestern University, University of Chicago, and University of Illinois Urbana-Champaign -- and a poster session showcasing cutting-edge research. Thank you to all of our speakers, presenters, and attendees for making this year’s Confab a success!

🔊 We are now accepting applications for New York Biohub’s Investigator Award Program. This program supports visionary scientists and engineers from #CZBiohubNY’s three partner institutions, Columbia University, The Rockefeller University, and Yale University, to do high-risk, high-reward research on deciphering the molecular language of immune cells, enabling these cells to be deployed for disease detection, prevention, and treatment. Learn more and apply by Dec. 9 ⤵️ https://lnkd.in/eP-VX3nt

👋🔬 Meet Sjoukje van der Stegen of the New York Biohub! Van der Stegen imagines a world where immunotherapy is as accessible as any prescription drug. As lead of the Immune Cell Engineering and Development Platform at the New York Biohub, she is working to generate engineered immune cells from induced pluripotent stem cells, or iPSCs, for a variety of uses, including immunotherapies. Read more about van der Stegen’s immune system research ⤵️ https://lnkd.in/gcFFQR6B #science #cancer #immunotherapy #iPSC #ImmuneSystem #CZBiohubNY

The Chicago Biohub is pursuing an audacious goal to “instrument” tissues to track and measure inflammation. Hear Shana Kelley explain how they’re doing it on this Inside Precision Medicine podcast! “We’re pursuing new technologies that allow us to study inflammation — listening in on the communication between immune cells and human tissues — for the first time,” she tells Jonathan Grinstein. “The large datasets we’re building will power AI models to simulate tissue-level inflammation and drive discovery.” Learn more: https://lnkd.in/gddUyPSb #CZBiohubCHI #science #inflammation

Hosted by the San Francisco Biohub, the 4th Physics of Life Symposium brought together over 200 participants from the San Francisco Bay Area and beyond, to discuss recent advances in research at the intersection of physics and biology. #ICYMI speaker videos are now online! View the playlist ⤵️ https://lnkd.in/gYUepGqP #CZBiohubSF #science #PhysicsofLife

“Soft” bioelectronic implants are much in demand for both research and clinical applications. Flexible, minimally invasive, and biocompatible, these devices could act as sensors to precisely monitor activity in tissues. Now, by tightly rolling up integrated circuits into a sort of bioelectronic jelly roll, Zhenan Bao and colleagues have created “Spiral-NeuroString,” an innovative device that packs a pile of functions into an implant the width of a human hair. As reported today in Nature (Nature Portfolio), in addition to incorporating hundreds to thousands of channels for powerful multimodal recording capabilities, the versatile new NeuroString can deliver electrical stimuli, drugs, and even light stimulation. Bao, Stanford University professor of chemical engineering and #CZBiohubSF Investigator, tells Stanford Report that, aside from its usefulness in science and medicine, NeuroString opens the door to a new era of smart fabrics and textiles, wearable devices, and soft robotics. Read more ➡️ https://lnkd.in/gNn6ZNQb

Looking for a one-stop shop to learn what’s happening across the Biohub Network? Check out our latest newsletter, including: 📢📝✨ CZI and the Biohub Network have launched two new RFAs. They will support advancing technologies for spatiotemporal omics in live tissue and the implementation of synthetic biology principles in immunology. 🎥🔬🧫 Watch a video about how new tools from #CZBiohubSF are pushing the limits of cell tracking. 👥💻🤝 More than 1,100 people participated in a CZ Imaging Institute crowdsourcing competition to develop algorithms that can automatically annotate 3D images of cells. For the full issue of Nexus ➡️ https://lnkd.in/g2b9pybM #CZBiohub #CZBiohubSF #CZBiohubCHI #CZBiohubNY

How did Shana Kelley, president of the Chicago Biohub, and her team create a first-of-its-kind biosensor to monitor inflammatory proteins? Check out her conversation with Eric Topol, MD! And learn more about the science behind these novel protein sensors here ⤵️ https://lnkd.in/gSmYsWEu #CZBiohubCHI #science #inflammation #inflammaging

🔊We’re excited to announce with Chan Zuckerberg Initiative two funding opportunities for scientists: two-year research projects in the areas of synthetic biology for immunology & spatial omics for instrumented tissues. ⭐ Aligning with the mission of the New York Biohub to harness the immune system for early disease detection and treatment, this RFA seeks innovative proposals to apply synthetic biology concepts to revolutionize our understanding of immune-related disorders. Learn more: https://lnkd.in/eH-52Bvw ⭐ Aligning with the mission of the Chicago Biohub to pioneer new tools for studying inflammation in human tissue in real time, this RFA seeks to develop minimally invasive technologies for proteomic and metabolomic profiling in live tissues. Learn more: https://lnkd.in/ehxbK5qC  Early-career investigators encouraged to apply!  #science #RFA #CZBiohubCHI #CZBiohubNY #immunology #inflammation #synbio