This was the first Lego video game developed by Traveller's Tales to have actual dialogue with a voice-over cast. (Lego Island from 1997 also featured voice acting) previous installments only had gibberish.
The first Lego DC game that included other DC Universe characters apart from the Bat-Family.
When you fly around the map as Superman, John Williams' iconic theme song plays.
Kevin Conroy and Mark Hamill were originally asked to voice Batman and the Joker respectively. However, they declined the offer due to scheduling conflicts with Batman: Arkham City (2011). They would eventually voice the characters in Lego DC Super-Villains (2018).