Rose Marie Dewitt and Ron Livingston are married in real life.
David Duchovny plays Kathleen Turner's nephew, but is only six years her junior in real life.
At around 17 mins David Duchovny (Richard) greets Anna Faris (Savanna) and Toni Collette (Macey) saying "Whassup?". The greeting originated in a USA Budweiser commercial but became globally popular from its first mainstream parody in Scary Movie (2000), Anna's breakout movie.
Reunites Rosemarie DeWitt with Toni Collette after the TV series United States of Tara. They play sisters.Rosemarie DeWitt and Toni Collette are cousins in this movie.
Anna Faris and Kathleen Turner both starred in Mom. Kathleen Turner played Tammy's Aunt Cookie in Season 7 episode 11 & 14.