The specialist Anna sees to help her cope with her disease is H. Langenkamp - a reference to Heather Langenkamp, the actress who played the would-be victim of fellow razor-blade killer Freddy Krueger in Les Griffes de la nuit (1984). Also when Anna picks up the newspaper showing a story about another slasher victim, the photo used is of Lisa Wilcox, also from A Nightmare on Elm Street 4 & 5.
This film reunites Milla Jovovich and Sandrine Holt, who previously collaborated on Resident Evil: Apocalypse (2004).