Sheryl Lee was hired for the recording session by accident, due to some mix up with the auditions. She plays one of the Splicers standing around a fire discussing what happened to Jack near the start.
Ken Levine, the series creator and writer of BioShock (2007) and BioShock Infinite (2013), was not involved with the development of this game, which led to some contradictions to the previously established continuity. For example, the character Sofia Lamb is said to have been a big political figure in Rapture and almost overthrew Andrew Ryan of his power, but it's specifically said in the first game that the only person to ever challenge his power was Frank Fontaine.
The Rumbler type of Big Daddy in this game is a revision of the SLOPRO Big Daddy which was cut from the first game. The initial concept for the character had the shoulder mounted cannon as seen in BioShock 2 but instead of being able to set up mini turrets, the SLOPRO held a massive hook which it used to perform lethal melee attacks.
Writer/Director Jordan Thomas stated that he enjoyed making the game; however, 2K (the company who owns the game) gave him a short development window and expected the same success from the first game.
The Xbox 360 version of BioShock 2 became backwards compatible for Xbox One on December 13th, 2016.