The movie is based off the Audible Original, "When You Finish Saving the World", which was also written by Jesse Eisenberg. The audio drama was released in August 4, 2020 and featured Finn Wolfhard, Kaitlyn Dever, and Jesse Eisenberg narrating as Ziggy Katz, Rachel Katz, and Nathan Katz, respectively.
Finn Wolfhard is the only actor to have performed in both the Audible Original and in the film adaptation of When You Finish Saving the World (2022). He plays Ziggy Katz in both versions.
When You Finish Saving the World (2022) marks the third film Finn Wolfhard and Billy Bryk have worked on together. The first film being S.O.S. fantômes: L'héritage (2021) and the second being Wolfhard's directorial debut short film, Night Shifts (2020). The two also host a podcast together called "Lackluster Video" for HeadGum.