Jahzir Bruno, who played Clyde McBride in this film, voiced the character in the sixth season of the original animated series, replacing Andre Robinson.
The film's producers cast the Bradley sisters in their respective roles not knowing that they were related. The crew did not figure out that they were related until their first day on set.
Brian Stepanek and Catherine Taber reprise their respective roles of Lynn Loud, Sr. and Katherine Mulligan from the original animated series.
This is the first time where Ella Allan and Mia Allan regularly wore completely different clothes from each other when acting together, since Mia plays Lana, an outdoorsy tomboy, and Ella plays Lola, a princess-obsessed girly-girl. In other works that the twin actresses appeared in, they often wore matching clothes.
Baby Lily was played by two actresses, Charlotte Ann Tucker and Lainey Knowles, because of the laws regarding young child actors and how long they can work each day. This rule didn't apply to the preteen children.