Aditi Sanwal playing the role of Lata is a real life Doctor. She completed her MBBS from M S Ramaiah Medical College, Bangalore, meanwhile playing a character of NEET aspirant in this series.
Pravin Yadav one of the writer of this Series is himself a Doctor. Some of the incidents and scenes are inspired from his own medical life journey from being a medical student to a Qualified Doctor.
The 2nd Season of 'Operation MBBS' was shot during the CoVID-19 pandemic and was released on 15th March, 2021 following the story of CoVID warriors.
Venkat the Skeleton is named after one of the producers of the show, Venkat Ravichander.