In this series, He-Man repeatedly uses the catchphrase "Lightning Strike!". In the Eighties, another cartoon hero based on a toy-line used a similar line, "Lightning Strikes!", namely the title character from Jayce et les conquérants de la lumière (1985).
The character of Ram Man, formerly a bulky male, is re imagined as a young female named Krass. This name was first given to the original version in the bio on the packaging of his Masters of the Universe Classics action figure.
This show portrays Duncan (Man-At-Arms) and Teela as young adults and peers, when previous "Masters of the Universe" shows have Teela as Duncan's daughter.
This is the first ever version of Skeletor not to wear a cape. This version is cape-less because flowing capes and robes are notoriously difficult to render in CGI animation.
Animation for the series is done by House of Cool and CGCG, which worked on Trollhunters and Star Wars: The Clone Wars.