Based on the novel: "Queen of the South" by Arturo Pérez-Reverte. Camila, a main character in the television series, does not exist in the book. The author's character was partly inspired by real-life Mexican drug lord Sandra Avila Beltran who was also known as "La Reina del Pacífico" (Queen of the Pacific).
Actor Hemky Madera (Pote) initially auditioned to play Alice Braga (Teresa)'s father but ended up playing her sicario and trusted friend instead.
Alice Braga, who portrays Mexican Drug Lord Teresa Mendoza is actually Brazilian, not Mexican.
Alice Braga dubbed her own voice for the Brazilian Portuguese airings of the series in the Space Brasil network.