As of 2021, Amanda Wendler, on whom this film was based, has been clean for four years. She and her mother Libby Alexander now advocate for addicts and their families.
Inspired by Amanda Wendler and Libby Alexander. Their picture appears at the very start of the credits.
Mila Kunis lost 20 pounds for the role and wore prosthetic "meth teeth" in the film. She was also covered in prosthetic scars and asked the film's hair designer to bleach her hair blonde and ruin it in the process.
Mila Kunis and Carla Gallo, who play sisters in this movie, were both in "Forgetting Sarah Marshall" as love interests to Jason Segel's character. In neither movie do the two actresses share any scenes.
Based on a 2016 Washington Post article by Eli Saslow, who co-wrote the screenplay with the director, Rodrigo García.