(at around 19 mins) Harvey Stephens, who portrayed Damien in La Malédiction (1976), appeared in this remake as the tabloid reporter who asks Robert Thorn (Liev Schreiber) if the deceased nanny "was on drugs".
This movie was released to coincide with the date of 06/06/06 in order to spark interest and gain publicity.
During filming, Seamus Davey-Fitzpatrick was never told that his character was supposed to be the son of the Devil. Julia Stiles has commented that it was because the filmmakers thought "he was too young to understand it, but he was really obedient when (producer and director) John (Moore) asked him for the Damien face."
The studio originally wanted this movie to receive an MPAA PG-13 rating, but producer and director John Moore insisted on an R-rating, suggesting people would "smell a cop-out" if a remake of La Malédiction (1976) was to receive a family-friendly certificate.
The role of Katherine Thorn was originally offered to Rachel Weisz, who declined because she was pregnant at the time. Other actresses considered for the part were Laura Linney, Hope Davis, and Alicia Witt, before Julia Stiles finally got the part. Stiles and Mia Farrow were both in a play together, and Stiles suggested to producer and director John Moore that they use Farrow for the role of Mrs. Blaylock (Damien's nurse). Initially, Moore didn't think that Farrow would accept the role, but Stiles convinced him she would. Eventually, he just rang up Farrow at her home and offered her the part.