David Walliams personally chose Anthony Head to play the Prime Minister. Whenever asked he answers "Because next to Steve Martin, he's the only man I'll ever turn gay for".
The characters Lou and Andy were originally created for Rock Profile (1999) where they were Lou Reed & Andy Warhol. The characters were changed slightly, but their relationship, and their voices, were established in the earlier show. They new characters retain the original first names.
In the week leading up to Christmas 2004, the DVD set of the show's first season was the UK's top selling DVD across all genres, and was the first non-theatrical title to top the charts in Britain since Riverdance had done in 1994.
Matt Lucas and David Walliams were both huge fans of Docteur Who (1963) as children and Little Britain contains a number of references to the series, including a character called Matthew Waterhouse (Matthew Waterhouse played the companion Adric in the 1980s) and another called Michael Craze (Michael Craze played the companion Ben Jackson in the 1960s). Tom Baker, who played the Doctor from 1974-1981, is the narrator. Lucas had played the Second Doctor in a "Doctor Who" parody in the third season of "Shooting Stars" before landing a recurring role as a companion for both Matt Smiths and Peter Capaldis Doctor. Walliams, however, only had a guest role in "Doctor Who" The God Complex (#6.11) as Gibbis. Colin Baker, who played the sixth Doctor, appeared in a deleted season 3 Emily & Florence sketch.
Graham Linehan: (director of the pilot episode) appears in the first of the two prime minister sketches, as the reporter from "Whizzer and Chips".