In a 2015 feature on National Public Radio, Jane Seymour said that although she eventually came to think of "Dr. Quinn" as one of the projects she is most proud of in her career, she originally signed her contract for it (including both the TV-movie/pilot and a five-year series commitment) with only one night's notice--not because she had any particular interest in the show but because she had just discovered that her then husband/business manager had lost all her money and gotten her $9 million in debt. She had told her agent that to avoid losing her house and to protect her two young children, she would do any TV project available no matter what it was, and Dr. Quinn was the first one offered to her.
Sully's dog "Wolf" was actually played by a number of dogs throughout the series. Contrary to popular belief, the breed is an Alaskan Malamute, not a husky.
Jane Seymour was the only cast member to appear and participate in all 149 episodes.
Larry Sellers (Cloud Dancing) was in charge of all of the Native American affairs, as he served as the series' historical consultant.
Beth Sullivan, who named Loren Bray after her grandfather, never intended for him to have a softer side. Her grandfather was a grumpy, mean man, and that was her idea for Loren's character. But Orson Bean had an immediate connection with Shawn Toovey on the set and it was impossible not to write that bond into the show.