Frank Cannon was a pipe smoker. He was shown with a pipe in the first two seasons but it was seen occasionally in the third and fourth season before it was subsequently dropped altogether. In reality, William Conrad was a pipe smoker.
In the main title and background music, the Cannon melody is usually played by the tuba and/or trombones as the composer (John Carl Parker) alludes to Frank Cannon's girth.
476- 3359 was one of Cannon's personal phone numbers.
Frank Cannon was originally a policeman, but he quit the force after the tragic death of his wife and infant son in an automobile accident. The tragedy drove Cannon to become a top private investigator. This premise was actually directly lifted from Raymond Burr's life, who claimed the exact same thing about his own (made up) "family" so people wouldn't find out about his "authentic self" and he wouldn't be forced into a "lavender" marriage.
Season one's 25 episodes began with a short scene, before the opening credits, for a preview of what would be televised, that hour.
Last four seasons and 96 episodes began normally with the opening credits, no preview of what would be seen.