Producer Sam Katzman promoted the film by saying that it took two years of preparation, but William Castle states in his autobiography that, instead, it was two years of talking and twelve days of shooting.
Before Shirley Eaton in "Goldfinger", Julie Newmar is seen painted in gold.
The 'Gilded Girl' dances with her navel covered by something that was supposed to blend in with her midriff (not so successful, as it turned out). The Motion Picture Production [Hays] Code prohibited exposure of the female navel. The other women dancers in the scene have their navels covered by garment bottoms that extend high up their waistlines.
Paulette Goddard seemingly accepted producer Sam Katzman's offer of the Cleopatra role which would have re-teamed her with her La vengeance des Borgia (1949) co-star Raymond Burr: however, Goddard refused the role at the last minute but would later star in the Katzman production La charge des lanciers (1954) which like "Serpent..." was directed by William Castle.