Charlize Theron gained fifty pounds for the role. She adhered to an excessive diet of junk food, processed foods, In-N-Out Burger, and milkshakes. Theron would eat macaroni and cheese at 2 a.m. to help keep on the weight. Theron said that her youngest child had mistaken her for being pregnant, given the extensive weight gain, and that it took a year and a half for her to shed the weight.
When Marlo asks Tully what she'll do tonight and Tully replies, "The same thing I do every night: try to take over the world!" she's paraphrasing the catchphrase from Minus et Cortex (1995).
This film reunites director Jason Reitman, writer Diablo Cody and star Charlize Theron, all of whom previously collaborated on Young Adult (2011). Reitman and Cody also previously collaborated on Juno (2007).
The film's release date was pushed back a week to avoid competition at the box office with Avengers: Infinity War (2018).
The film premiered at the 2018 Sundance Film Festival.