The show is loosely inspired by Will Arnett's past experiences with alcoholism. He let his 15-year sobriety briefly lapse during the filming of the first season of the show.
Each episode is titled after a real street name in the Venice / Santa Monica area.
At the beginning of each show, the words A Netflix Original Series appears and then the letters disappear a few at a time. The last letters that are shown together make up the word lies, which is what the series is based around.
One of the wine brands visible in Dennis' cellar is Frass Canyon. Frass Canyon is a fictional winery featured in the movie Sideways.
The bicycle Chip rides during the show is made by Linus. These bikes are made and sold in Venice, CA where the show also takes place.