Uncle Casey gives Owen's dog Brutus the nickname of T-Bone, in reference to Clifford's best dog friend in Clifford, o Gigante Cão Vermelho (2000).
In the closing credits, Clifford is alongside a mural that has him painted in his animated/illustrated look from the books and cartoons.
2nd theatrical film based off of the Clifford the Big Red Dog book series, after Clifford, o Gigante Cão Vermelho: O Filme (2004) from Warner Bros., which was a film that served as a closing point to the Clifford, o Gigante Cão Vermelho (2000) television series under the same continuity/format.
Kenan Thompson, who plays Clifford's veterinarian, had a guest role in Clifford, o Gigante Cão Vermelho (2000), where he voiced a dog named Hamburger, the best friend of T-Bone (voiced by Thompson's longtime comedy partner Kel Mitchell).