The earring that Lisa wears is the Ancient Egyptian cross called Ankh, aka the "cross of life" or "the key of life". The Ankh, and its symbolism, can be dated back to the Early Dynastic Period, ranging from c. 3150 - 2613 BCE. The Egyptians believed that their time here on Earth was merely just a part of a larger eternal life, as the ankh symbolizes both the afterlife and a mortal existence on earth.
Posters seen on Lisa's bedroom are from English artists Tears for Fears, David Bowie, The Smiths, Siouxsie and the Banshees and The Cure.
Vincenzo Natali said that he was drawn to the film because, unlike Splice (2009), which took him twelve years to complete, Haunter only needed to be shot.
Production for the film took place over 25 days.
Abigail Breslin had a severe asthma attack while filming.