This is the second television series starring Gillian Anderson with a scene in the pilot episode in which a man spray-paints an X on a remote country road and that X later plays an important role in the plot; the first was Arquivo X (1993).
Rachael Taylor and Lance Gross have both played doctors in A Anatomia de Grey (2005) but in different seasons.
This is the second show where Dermot Mulraney and Halston Sage acted together. The first was Prodigal Son