China Anne McClain and Melanie Paxson are the only cast members from the previous Descendants films to reprise their roles. McClain appeared in both of the film's sequels and Paxson appeared in all three films.
Brandy and Paolo Montalban both reprise their roles as Cinderella and King Charming from Rodgers and Hammerstein's Cinderella (1997).
This film was teased at the end of Descendants: The Royal Wedding (2021), at the end when Mal and Ben are looking at the night sky Mal says to Ben, "But somewhere another story could be just beginning." and the camera shows a bed of white roses covered with red paint, and the camera pans down a rabbit hole.
This movie continues the tradition of ending the movie with the famous line, "You didn't think this was the end of the story... Did you?"
In the film, the Queen of Hearts (Rita Ora) and Cinderella (Brandy) were once classmates. In real life, Rita Ora and Brandy are 11 years apart.