Filming took place in New York City over a course of 12 days.
Edward Burns invited fans via Twitter to hand in potential posters for "Newlyweds (2011)." The winner's poster would be used at the Tribeca Film Festival. The winner would also receive tickets to see "Newlyweds (2011)" at the festival and a copy of the DVD when the film came out.
Kerry Bishe and Marsha Dietlein had co-starred in Edward Burns's previous film "Os Amores de Johnny (2010)."
Daniella Pineda's debut.